AβPP Accumulation and/or Intraneuronal Amyloid-β Accumulation? The 3xTg-AD Mouse Model Revisited
Open accessAbstract
The triple-transgenic Alzheimer's disease (AD) mouse model, 3xTg-AD, played an important role in supporting the intraneuronal amyloid-β (Aβ) hypothesis in AD. However, recent evidence claims that the 3xTg-AD mice accumulate amyloid-β protein precursor (AβPP) instead of Aβ within neurons. In the present report, we re-investigated the 3xTg-AD mouse model and confirmed recent findings of age-dependent AβPP accumulations. In addition, intraneuronal Aβ was detected mainly in the neocortex using conformation-specific as well as antibodies directed against Aβ neo-epitopes. In contrast to previous work, however, only minor levels of intraneuronal Aβ were detected in the CA1 region of the hippocampus in aged 3xTg-AD mice.
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The discrepancy in intraneuronal Aβ levels in 3xTg mice might be due to APP cross-reacting antibodies such as 6E10 or 4G8, which detect central Aβ epitopes and also pick up full-length APP, resulting in overestimation of effective intraneuronal Aβ levels in the hippocampus.
“This discrepancy to the abovementioned data in models with intraneuronal Aβ accumulation might be due to the use of APP cross-reacting antibodies (such as 6E10 or 4G8), which have been frequently used for Aβ labelling [111]. As these antibodies detect central Aβ epitopes, they usually also pick-up considerable levels of full-length APP, resulting in an overestimation of the effective intraneuronal”
From Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models (2020) · cites this paper as [112]
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References 28 · Cited by 26
- Authors
- Wirths, O., Dins, A., & Bayer, T. A.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Wirths, Oliver
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2012-02-20
- Volume
- 28
- Issue
- 4
- Pages
- 897-904
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1519289543
- Cited by
- 26
- References
- 28
- Citations by year
- 2025: 1 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- 3xTg-AD mice, amyloid precursor protein
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Mice, Transgenic, Neurons, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Neocortex, Mice
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