Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer’s Disease Risk

Cao, Han; Alzheimer’s Disease Neuroimaging Initiative; Zhou, Xiaopu; Chen, Yu; Ip, Fanny C.F.; Chen, Yuewen; Lai, Nicole C.H.; Lo, Ronnie M.N.; Tong, Estella P.S.; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Fu, Amy K.Y.; Ip, Nancy Y.

doi:10.3233/jad-215311

Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer’s Disease Risk

Background: Genetic studies reveal that single-nucleotide polymorphisms (SNPs) of SPI1 are associated with Alzheimer’s disease (AD), while their effects in the Chinese population remain unclear. Objective: We aimed to examine the AD-association of SPI1 SNPs in the Chinese population and investiga…