The Intestinal Barrier in Parkinson’s Disease: Current State of Knowledge
Open accessAbstract
The intestinal barrier, which primarily consists of epithelial cells stitched together with connecting proteins called tight junctions, plays a critical role in health and disease. It is in close contact with the gut microbiota on its luminal side and with the enteric neurons on the tissue side. Both microbiota and the enteric nervous system are regulatory housekeepers of the intestinal barrier. Therefore, the recently observed enteric neuropathology along with gut dysbiosis in Parkinson’s disease have prompted research on intestinal permeability in this neurodegenerative disorder. In this mini-review we attempt to concisely summarize the current knowledge on intestinal barrier in Parkinson’s disease. We envision future direction research that should be pursued in order to demonstrate its possible role in disease development and progression.
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Parkinson's disease patients and animals have increased intestinal permeability.
“PD patients and animals have both been found to have increased intestinal permeability in previous studies [61,62].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [61]
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References 36 · Cited by 97
- Authors
- van IJzendoorn, S. C. D., & Derkinderen, P.
- Affiliations
- Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
- Inserm (FR)
- ORCID
- Derkinderen, Pascal
- Venue
- Journal of Parkinson’s Disease
- Publisher
- SAGE Publications
- Published
- 2019-09-20
- Volume
- 9
- Issue
- s2
- Pages
- S323-S329
- ISSN
- 1877-7171 (ISSN-L)
- 1877-718X
- PMC
- PMC6839484
- OpenAlex
- W2973963952
- Cited by
- 97
- References
- 36
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 18 · 2023: 14 · 2022: 22 · 2021: 17 · 2020: 4 · 2019: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Parkinson s Disease (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Parkinson's disease, intestinal barrier, tight junctions, gut microbiota, gut dysbiosis, enteric nervous system, intestinal permeability, neurodegeneration
- MeSH terms
- Gastrointestinal Microbiome, Humans, Intestinal Diseases, Intestinal Mucosa, Parkinson Disease, Enteric Nervous System, Tight Junctions, Tight Junction Proteins, Dysbiosis
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