Minocycline Mitigation of Tremor Syndrome and Defect of Cognitive and Balance Induced by Harmaline
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INTRODUCTION: Minocycline has anti-inflammatory, anti-apoptotic, and anti-oxidant effects. Preclinical data suggest that minocycline could be beneficial for treating common neurological disorders, including Parkinson disease and multiple sclerosis. METHODS: In this study, the effects of minocycline on harmaline-induced motor and cognitive impairments were studied in male Wistar rats. The rats were divided into four groups of ten animals each. Harmaline was used for the induction of Essential Tremor (ET). Minocycline (90 mg/kg, IP) was administered 30 minutes before the saline or harmaline. Tremor intensity, spontaneous locomotor activity, passive avoidance memory, anxiety-related behaviors, and motor function were assessed in the rats. RESULTS: The results showed that minocycline could recover tremor intensity and step width but failed to recuperate the motor balance. The memory impairments observed in harmaline-treated rats were somewhat reversed by administration of minocycline. The cerebellum and inferior olive nucleus were studied for neuronal degeneration using histochemistry and transmission electron microscopy techniques. Harmaline caused ultrastructural changes and neuronal cell loss in inferior olive and cerebellar Purkinje cells. Minocycline exhibited neuroprotective changes on cerebellar Purkinje cells and inferior olivary neurons. CONCLUSION: These results open new therapeutic perspectives for motor and memory impairments in ET. However, further studies are needed to clarify the exact mechanisms.
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Minocycline molecular changes explain increased striatal dopamine levels and cognitive and locomotor improvements in zebrafish, mouse, and rat models.
“Of note, these molecular changes seem to explain the increased striatal dopamine levels as well as the cognitive and locomotor improvements observed in zebrafish, mouse, and rat models [259,260,264,268,269,270,271].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [269]
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References 73 · Cited by 4
- Authors
- Department of Physiology, P. R. C., Maneshian, M., Nasirinezhad, F., Department of Physiology, P. R. C., Mohammadi, F., Intracellular Recording Lab, N. R. C., Behzadi, M., Intracellular Recording Lab, N. R. C., Asadi-Shekaari, M., Intracellular Recording Lab, N. R. C., Shabani, M., & Intracellular Recording Lab, N. R. C.
- Affiliations
- Iran University of Medical Sciences (IR)
- Kerman University of Medical Sciences (IR)
- Corresponding author
- Shabani, Mohammad
- Venue
- Basic and Clinical Neuroscience Journal
- Publisher
- Negah Scientific Publisher
- Published
- 2021-03-01
- Volume
- 12
- Issue
- 2
- Pages
- 255-268
- ISSN
- 2008-126X (ISSN-L)
- 2228-7442
- PMC
- PMC8672663
- OpenAlex
- W3138242120
- Cited by
- 4
- References
- 73
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Basic and Clinical Neuroscience Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Kerman University of Medical Sciences
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- minocycline, harmaline, essential tremor, neuroprotection, Purkinje cells, inferior olive, neurodegeneration, memory impairment, locomotor activity, anxiety, oxidative stress
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