Cell Biology of Respiration-deficient Mutants of Candida albicans
Open accessAbstract
Respiration-deficient (petite) mutation is caused by hereditary impairment in mitochondrial functions. Yeasts have been grouped into "petite-positive" and "petite-negative" yeasts. Candida albicans has been regarded as a member of the petite-negative yeasts in which the respiration deficiency cannot be easily induced. We have succeeded in inducing the petite mutation in C. albicans by culturing in the presence of a chemical mutagen, acriflavine, at an elevated temperature. In the present review, we describe the cell biology of C. albicans petite mutants on the basis of experiments performed by our research group: namely, on respiratory activity and cytochrome composition, fine structures of cells and mitochondria, mitochondrial DNA structure, pathogenicity, oxidative stress sensitivity, generation of reactive oxygen species (ROS) and the roles of ROS in antifungal actions. We discuss also the usefulness of petite mutants in Candida research.
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Most other described C. albicans petite strains are induced by harsh chemical treatments, making correlations of specific mitochondrial dysfunctions with azole resistance difficult to interpret.
“Other C. albicans petite strains have been described, but most are induced by harsh chemical treatments, and therefore, correlations of specific mitochondrial dysfunctions with azole resistance are more difficult to interpret (15–17).”
From Azole Susceptibility and Transcriptome Profiling in Candida albicans Mitochondrial Electron Transport Chain Complex I Mutants (2013) · cites this paper as [15]
The Abstract (page not specified) says the authors induced C. albicans petite mutants using the chemical mutagen acriflavine at elevated temperature. It does not establish that most other described strains were induced by harsh chemical treatments or say that such treatments make mitochondrial dysfunction–azole resistance correlations difficult to interpret. (LLM, conf=0.84)
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References 23 · Cited by 2
Research works printed but not linked: 1
- Aoki S, Yamaguchi H: Isolation and characterization of petite mutants of Candida albicans. In: Molecular Biology of Pathogenic Fungi: A Laboratory Manual (Maresca B, Kobayashi GS eds). p.207-211, Telos Press. New York. 1994.
- Authors
- Aoki, S., Ito-Kuwa, S., Nakamura, K., & Nakamura, Y.
- Affiliations
- Nippon Dental University (JP)
- ORCID
- Nakamura, Yasunori
- Venue
- Nippon Ishinkin Gakkai Zasshi
- Published
- 2005
- Volume
- 46
- Issue
- 4
- Pages
- 243-247
- ISSN
- 0916-4804 (ISSN-L)
- 1882-0476
- OpenAlex
- W2322734356
- Cited by
- 2
- References
- 23
- Citations by year
- 2017: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- ja
- Open access
- bronze
- doi.org
- Locations
- Nippon Ishinkin Gakkai Zasshi (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Candida albicans, petite mutation, respiration-deficient mutants, mitochondrial dysfunction, mitochondrial DNA, pathogenicity, oxidative stress sensitivity, reactive oxygen species, antifungal mechanism, yeast cell ultrastructure
- MeSH terms
- Animals, Candida albicans, DNA, Mitochondrial, Microbiological Techniques, Mitochondria, Mutation, Superoxide Dismutase, Reactive Oxygen Species
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