Multiple regulatory mechanisms act in concert to control ferroportin expression and heme iron recycling by macrophages
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The daily production of new erythrocytes by the bone marrow is a process which makes big demands on body iron stores and the erythroid activity of the bone marrow regulates the control of iron homeostasis. Tissue macrophages, especially in the spleen and liver, play a major role in controlling the
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These regulations are direct effects of free intracellular heme, which causes BACH1 to derepress SpiC.
“The latter regulations are direct effects of free intracellular heme, which causes BACH1 to derepress SpiC (Beaumont, 2010;Sun et al., 2002).”
From Iron in infection and immunity (2020) · cites this paper as Beaumont, 2010
The paper’s discussion of heme-dependent transcription (page not supplied) says that heme inhibits Bach1’s DNA-binding activity and describes Bach1-dependent regulation of ferroportin. It does not mention SpiC or establish that Bach1 derepresses SpiC, so that specific part of the claim is unsupported by this source. (LLM, conf=0.86)
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References 29 · Cited by 37
Research works printed but not linked: 2
- Vol. 95 No. 8 (2010): August, 2010 : Editorials https://doi.org/10.3324/haematol.2010.025585
- Carole Beaumont. Multiple regulatory mechanisms act in concert to control ferroportin expression and heme iron recycling by macrophages. Haematologica 2010; 95(8):1233-1236; https://doi.org/10.3324/haematol.2010.025585.
- Authors
- Beaumont, C.
- Affiliations
- Inserm (FR)
- Corresponding author
- Beaumont, C.
- Venue
- Haematologica
- Published
- 2010-07-31
- Volume
- 95
- Issue
- 8
- Pages
- 1233-1236
- ISSN
- 0390-6078 (ISSN-L)
- 1592-8721
- PMC
- PMC2913068
- OpenAlex
- W2122530626
- Cited by
- 37
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 2
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Haematologica (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- ferroportin, macrophages, iron homeostasis, erythropoiesis, spleen, liver, gene expression regulation
- MeSH terms
- Ferroportin, Animals, Cell Line, Heme, Hemoglobins, Iron, Macrophages, Models, Biological, Promoter Regions, Genetic, Regulatory Sequences, Nucleic Acid, Transcription, Genetic, Membrane Microdomains, Antimicrobial Cationic Peptides, Cation Transport Proteins, Basic-Leucine Zipper Transcription Factors, NF-E2-Related Factor 2, Mice, Heme Oxygenase-1, Hepcidins
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