Spray-dried snail mucus as raw material with potential for chronic wound treatment
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Studies [71,72,73] could be a prerequisite for development of sun protective products for skin care with addition of snail mucus.
“Studies [71,72,73] could be a prerequisite for the development of sun protective products for skin care with the addition of snail mucus.”
From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [72]
The Results and discussion report antioxidant activity in snail mucus, and the Conclusion identifies spray-dried mucus as a potential raw material for chronic wounds and other skin-related conditions. The paper does not examine sun protection, UV exposure, or a sun-protective product, so it supports the proposed skin-care ingredient only at a broader level. (LLM, conf=0.82)
Experimental — accuracy not yet measuredDried powdery extract of snail mucus caused dose-dependent and time-dependent activation of keratocyte proliferation at concentrations 0.01, 0.1, and 1 mg/mL, increasing proliferation at 72 h (80.15%, 70.63%, 69.38%) compared to 48 h (73.11%, 61.31%, 59.38%).
“The dried powdery extract of snail mucus caused a dose-dependent and time-dependent activation of keratocyte proliferation in the tested concentrations (0.01, 0.1, and 1 mg/mL). It increased proliferation at 72 h (80.15%, 70.63%, and 69.38%, respectively) compared to 48 h (73.11%, 61.31%, and 59.38%, respectively).”
From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [72]
The Results and discussion (pp. 317–318) report the stated concentrations, 48- and 72-hour proliferation values, and concentration- and time-dependent response. However, the Methods identify the tested cells as HaCaT keratinocytes, not keratocytes. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIntroduction of snail mucus into fibroblast culture promoted its viability and effectively counteracted basal expression of COX-2, depending on concentration.
“The introduction of snail mucus into the fibroblast culture promoted its viability and effectively counteracted the basal expression of cyclooxygenase-2 (COX-2), depending on the concentration of the snail mucus.”
From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [72]
The Results and discussion section reports concentration- and time-dependent proliferation of HaCaT keratinocytes after exposure to snail mucus. The Materials and methods section identifies the culture as keratinocytes, not fibroblasts; our copy reports no measurement of basal COX-2 expression. Thus the cell-growth aspect has support, but the specified cell type and COX-2 effect do not. (LLM, conf=0.88)
Experimental — accuracy not yet measuredDried powdery extract of snail mucus showed pronounced antioxidant potential in ORAC test.
“It also showed pronounced antioxidant potential in the ORAC (oxygen radical absorbance capacity) test [72].”
From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [72]
The Materials and methods section says the spray-dried mucus was assessed with an ORAC assay, and Results and discussion reports an antioxidative effect that increased with concentration. The paper does not describe the effect as pronounced; it reports fluorescence values of 103.3% to 106.4% after two hours. (LLM, conf=0.83)
Experimental — accuracy not yet measuredAn effect of decrease in number of alive cells (keratinocytes and macrophages) was revealed for high concentration of snail mucus (diluted 1:20).
“An effect of a decrease in the number of alive cells (keratinocytes and macrophages) was revealed for the high concentration of the snail mucus (when diluted 1:20).”
From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [72]
The Results and discussion section (pp. 317–318) reports lower HaCaT keratinocyte proliferation percentages at higher tested mucus concentrations, which partly supports a concentration-related effect. It does not report macrophage results or a 1:20 dilution, and its proliferation percentages do not directly establish a decrease in the number of living cells. (LLM, conf=0.82)
Experimental — accuracy not yet measured
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Cites
Advancing Discovery of Snail Mucins Function and Application
McDermott, M., Cerullo, A. R., Parziale, J., Achrak, E., Sultana, S., Ferd, J., Samad, S., Deng, W., Braunschweig, A. B., & Holford, M. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.734023 · Cited by 77 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
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- Santos-Vizcaino, E., Salvador, A., Vairo, C., Igartua, M., Hernandez, R.M., Correa, L., Villullas, S. and Gainza, G., 2020. Overcoming the inflammatory stage of non-healing wounds: in vitro mechanism of action of negatively charged microspheres (NCMs). Nanomaterials 10(6), 1108. https://doi.org/10.3390/nano10061108. · DOI
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- Waluga-Kozlowska, E.W.A., Jasik, K., Wcislo-Dziadecka, D., Pol, P., Kuznik-Trocha, K., Komosinska-Vassev, K., Olczyk, K., Waluga, M., Olczyk, P and Zimmermann, A., 2021. Snail mucus-A natural origin substance with potential use in medicine. Acta Pol. Pharm. 178, 793-800. https://doi.org/10.32383/appdr/145377. · DOI
Cited by
Sorted by citations
Hudz, N., Turkina, V., Alyokhina, T., Motyka, O., Chemerys, N., Rumynska, T., Lozynskyi, A., Jasicka-Misiak, I., & Kobylinska, L. (2025) · Molecules · doi:10.3390/molecules30214197 · Cited by 4 · see citing works
- Authors
- Tasevska, T., Glavas Dodov, M., Shalabalija, D., Mihailova, L., Polenakovic, R., & Simonoska Crcarevska, M.
- Affiliations
- Ss. Cyril and Methodius University in Skopje (MK)
- Institute of Pharmaceutical Technology and Center of pharmaceutical nanotechnology, Faculty of Pharmacy, Ss. Cyril & Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, R. North Macedonia
- Venue
- Macedonian Pharmaceutical Bulletin
- Published
- 2022-12-31
- Volume
- 68
- Issue
- 03
- Pages
- 317-318
- ISSN
- 1409-8695 (ISSN-L)
- 1857-8969
- OpenAlex
- W4319998695
- Cited by
- 2
- References
- 1
- Citations by year
- 2025: 1 · 2023: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Macedonian Pharmaceutical Bulletin (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- snail mucus, spray drying, chronic wounds, wound healing, biomaterials, raw materials
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