An Innovative PN HPT™-based Medical Device for the Therapy of Deteriorated Periocular Skin Quality
Open accessAbstract
Objective: Polynucleotides Highly Purified Technology (PN HPT™) hydrate the extracellular matrix and fill the depressed dermal spaces in the periocular areas with skin quality problems; moreover, PN HPT™ replenish the nucleotide precursor pool. Within a long-term monitoring program, the questionnaire-based survey aimed to confirm the profile of known side effects and contraindications. Methods: Survey base: A real-world cohort of 48 ambulatory outpatients with periocular skin quality problems after a three-session intradermal injection cycle with 15 mg of PN HPT™- based gel in disposable syringes PLINEST eye, Mastelli S.r.l., Sanremo, Italy). Study purpose: Confirming the PN HPT™ persisting efficacy and safety in improving facial and periocular skin quality and texture. Assessment tools: Investigator-assessed Wrinkle Severity Rating Scale (WSRS) and investigator- and subject assessed Global Aesthetic Improvement Scale (GAIS) at baseline and four weeks after the last PN HPT™ intradermal injection. Results: The mean whole-cohort WSRS score improved from 3.3 ± 0.93 at baseline to 1.8 ± 0.90 at the final follow up visit (–45.5%, p<0.0001), including in the 39 cohort outpatients with hypotrophic skin (–46.9%, p<0.0001). According to investigators, 87.5% of cohort subjects and outpatients were GAIS responders, with 50% “Much improved” or “Very much improved”. “Much improved” and “Very much improved” were the self-assessed GAIS ratings for 56.3% of surveyed subjects. Limitations: Brief overall follow-up, lack of a control group. Conclusion: PN HPT™ retain the usual excellent value and safety in improving skin quality in the periocular region with no variations over time and no differences in subjects with correctly structured or hypotrophic skin.
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A PN-based medical device incorporating HPT®, developed by Mastelli S.R.L., significantly improved facial wrinkles and skin roughness, as measured using three-dimensional skin imaging and the global esthetic improvement scale (GAIS).
“The use of a PN-based medical device incorporating HPT®, developed by Mastelli S.R.L., significantly improved facial wrinkles and skin roughness, as measured using three-dimensional skin imaging and the global esthetic improvement scale (GAIS) [165,166].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [166]
The Acknowledgements identify Mastelli S.r.l. as the developer, and the Efficacy outcomes report significant improvements in periocular and facial wrinkles assessed with WSRS, alongside favorable GAIS ratings. The paper does not report three-dimensional skin imaging or a separate measure of skin roughness; its assessments were WSRS and GAIS. (LLM, conf=0.88)
Experimental — accuracy not yet measuredPlacentex® is a PDRN-based therapeutic developed by Mastelli S.R.L. in Italy.
“A notable example is Placentex®, a PDRN-based therapeutic developed by Mastelli S.R.L. in Italy.”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [166]
The Acknowledgements (page unavailable) say that Mastelli S.r.l. in Italy developed the PN HPT™ technology and the injectable periocular gel tested in this study. The Methods identify that product as PLINEST eye, not Placentex®. Our copy does not identify Placentex® or describe it as PDRN-based, so the claim about that specific therapeutic is unsupported. (LLM, conf=0.82)
Experimental — accuracy not yet measuredPlacentex® is manufactured using a proprietary High Purification Technology (HPT) designed to enhance purity and partially control the polymer length.
“This product is manufactured using a proprietary High Purification Technology (HPT) designed to enhance purity and partially control the polymer length [165,166].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [166]
The Introduction describes a patented purification process that produces a pure ingredient with polynucleotide fragments of 50–2,000 base pairs, supporting the purity and polymer-length portions of the claim. But the paper identifies the studied product as PLINEST eye (Abstract), not Placentex®, and does not establish that Placentex® is manufactured using this technology. Page numbers were not available in our copy. (LLM, conf=0.86)
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Cites
A Classification of Facial Wrinkles
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Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
- Authors
- Palmieri, I. P., Moro, L., Fraone, N., De Luca, C., & Prussia, C.
- Affiliations
- Federico II University Hospital (IT)
- Venue
- Surgical Research
- Publisher
- SciVision Publishers LLC
- Published
- 2023-09-30
- Volume
- 5
- Issue
- 3
- ISSN
- 2689-1093 (ISSN-L)
- OpenAlex
- W4388707566
- Cited by
- 2
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Surgical Research (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- polynucleotides, wrinkle severity, intradermal injection, skin rejuvenation, nucleotide precursors, aesthetic improvement, safety and side effects
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