The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Therapeutic Effects of Topical Application of Ozone on Acute Cutaneous Wound Healing
Open accessAbstract
This study was undertaken to evaluate the therapeutic effects of topical ozonated olive oil on acute cutaneous wound healing in a guinea pig model and also to elucidate its therapeutic mechanism. After creating full-thickness skin wounds on the backs of guinea pigs by using a 6 mm punch biopsy, we examined the wound healing effect of topically applied ozonated olive oil (ozone group), as compared to the pure olive oil (oil group) and non-treatment (control group). The ozone group of guinea pig had a significantly smaller wound size and a residual wound area than the oil group, on days 5 (P<0.05) and 7 (P<0.01 and P<0.05) after wound surgery, respectively. Both hematoxylin-eosin staining and Masson-trichrome staining revealed an increased intensity of collagen fibers and a greater number of fibroblasts in the ozone group than that in the oil group on day 7. Immunohistochemical staining demonstrated upregulation of platelet derived growth factor (PDGF), transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor (VEGF) expressions, but not fibroblast growth factor expression in the ozone group on day 7, as compared with the oil group. In conclusion, these results demonstrate that topical application of ozonated olive oil can accelerate acute cutaneous wound repair in a guinea pig in association with the increased expression of PDGF, TGF-beta, and VEGF.
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Cites
Expression and Proteolysis of Vascular Endothelial Growth Factor is Increased in Chronic Wounds
Lauer, G., Sollberg, S., Cole, M., Krieg, T., Eming, S. A., Flamme, I., Stürzebecher, J., & Mann, K. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00036.x · Cited by 349
The dual action of ozone on the skin
Valacchi, G., Fortino, V., & Bocci, V. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06939.x · Cited by 243
Cited by
Skin Wound Healing and Phytomedicine: A Review
Pazyar, N., Yaghoobi, R., Rafiee, E., Mehrabian, A., & Feily, A. (2014) · Skin Pharmacology and Physiology · doi:10.1159/000357477 · Cited by 275
Donato-Trancoso, A., Monte-Alto-Costa, A., & Romana-Souza, B. (2016) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2016.03.012 · Cited by 112
Metadata
- Authors
- Kim, H. S., Noh, S. U., Han, Y. W., Kim, K. M., Kang, H., Kim, H. O., & Park, Y. M.
- Venue
- Journal of Korean Medical Science
- Publisher
- Korean Academy of Medical Sciences
- Published
- 2009
- Volume
- 24
- Issue
- 3
- Pages
- 368
- ISSN
- 1011-8934 (ISSN-L)
- OpenAlex
- W2128519425
- Cited by
- 231
- References
- 2
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kim, H. S., Noh, S. U., Han, Y. W., Kim, K. M., Kang, H., Kim, H. O., & Park, Y. M. (2009). Therapeutic Effects of Topical Application of Ozone on Acute Cutaneous Wound Healing. Journal of Korean Medical Science. https://doi.org/10.3346/jkms.2009.24.3.368
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
