The DOI matches its Crossref record.
A case of acute cholestatic hepatitis induced by Corydalis speciosa Max
Abstract
Herbs are widely used as treatments for various symptoms. However, several herbs have been reported to be inducers of liver injury. We report herein a case of hepatotoxicity induced by Corydalis speciosa Max. A 37-year-old male complained of jaundice and mild abdominal discomfort. A thorough history was taken, and laboratory investigation, diagnostic imaging studies, and percutaneous liver biopsy sampling were conducted to determine the cause of liver injury. An accurate cause was not revealed. We administered supportive management for acute cholestatic hepatitis of unknown origin, after which his symptoms disappeared and serum aminotransferase levels decreased gradually to near normal levels. However, at 2 months after discharge, the symptoms and the elevation of aminotransferase levels recurred. At that time he told us that he had repeatedly but unintentionally eaten a herb called "Hwang-geun cho"(Corydalis speciosa Max.). Thus, we diagnosed his case as herbal hepatotoxicity.
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Kang et al. described a patient with a positive re-exposure result, as evidenced by a striking increase of serum ALT activity shown in a separate figure and likely following the test criteria published earlier.
“Valuable is, also, the report of Kang et al.,44 who described a patient with a positive re-exposure result, as evidenced by a striking increase of serum alanine aminotransferase (ALT) activity shown in a separate figure and likely following the test criteria published earlier.15”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [44]
First authors of reports from Korea contributed as experts were numbered overall 15, and thereby represented a substantial number of publications on 526 HILI cases that had been assessed for causality using RUCAM.
“First authors of reports from Korea contributed as experts were numbered overall 15, and thereby represented a substantial number of publications on 526 HILI cases that had been assessed for causality using RUCAM (Table 1).40–54”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [44]
Shortcomings in Korean articles included use of a RUCAM version modified by the authors for unknown reasons without own method re-validation.
“These included, for instance, the use of a RUCAM version modified by the authors for unknown reason(s) without own method re-validation,40,44,51,53”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [44]
It seems that most Korean reports followed a retrospective study approach.
“It seems that most reports followed a retrospective study approach (Table 1),40–54”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [44]
Citations
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No references could be resolved yet.
Research works printed but not linked: 20
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- Lee, 2006, New Flora of Korea, 452
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Cited by
Sorted by citations
Teschke, R., Zhu, Y., & Jing, J. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00009 · Cited by 41
Metadata
- Authors
- Kang, H. S., Choi, H. S., Yun, T. J., Lee, K. G., Seo, Y. S., Yeon, J. E., Byun, K. S., Um, S. H., Kim, C. D., & Ryu, H. S.
- Affiliations
- Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
- Venue
- The Korean Journal of Hepatology
- Published
- 2009
- Volume
- 15
- Issue
- 4
- Pages
- 517
- ISSN
- 1738-222X
- Cited by
- 14
- References
- 0
- Language
- ko
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