Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment
Open accessAbstract
Heroin addiction markedly affects the nutritional and metabolic status and frequently leads to malnutrition. The aim of our study was to compare circulating concentration of adipose tissue-derived hormones leptin, adiponectin and resistin in 12 patients with heroin addiction before and after one-year methadone maintenance treatment with the group of 20 age- and body mass index-matched healthy subjects. Basal serum leptin and adiponectin levels in heroin addicts were significantly decreased (3.4+/-0.4 vs. 4.5+/-0.6 ng/ml and 18.9+/-3.3 vs. 33.9+/-3.1 ng/microl, respectively; p 0.05) while serum resistin concentrations were increased compared to healthy subjects (10.1+/-1.2 vs. 4.6+/-0.3 ng/ml; p 0.05). Moreover, positive correlation of serum leptin levels with body mass index was lost in the addicts in contrast to control group. One year of methadone maintenance treatment normalized serum leptin, but not serum adiponectin and resistin concentrations. In conclusion, circulating concentrations of leptin, adiponectin and resistin are markedly altered in patients with chronic heroin addiction. These alterations appear to be relatively independent of nutritional status and insulin sensitivity.
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It is possible that altered hormones associated with heroin addiction contribute to abnormal weight changes and/or decreased bone mass.
“It is possible that altered hormones associated with heroin addiction contribute to abnormal weight changes (157) and/or decreased bone mass (158).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [157]
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References 26 · Cited by 52
- Authors
- Housová, J., Wilczek, H., Haluzík, M., Křížová, J., & Haluzík, M.
- Affiliations
- University of Ostrava (CZ)
- ORCID
- Křížová, J
- Venue
- Physiological Research
- Published
- 2005
- Volume
- 54
- Issue
- 1
- Pages
- 73-78
- ISSN
- 0862-8408 (ISSN-L)
- 1802-9973
- OpenAlex
- W2135916265
- Cited by
- 52
- References
- 26
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Physiological Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- heroin addiction, methadone maintenance treatment, leptin, adiponectin, resistin, adipose tissue hormones, malnutrition, body mass index, insulin sensitivity, chronic opioid use
- MeSH terms
- Adult, Chronic Disease, Female, Heroin Dependence, Hormones, Hormones, Ectopic, Humans, Male, Methadone, Narcotics, Nutritional Status, Body Mass Index, Adipocytes, Leptin, Intercellular Signaling Peptides and Proteins, Adiponectin, Resistin
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