Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overweight/obese adults: a pilot study
Open accessAbstract
The novel myokine irisin has been reported as a therapeutic target for metabolic disease. The objective of this study is to reveal the effects of aerobic training (AT) and resistance training (RT) on circulating irisin levels and their associations with change of body composition in overweight/obese adults. Twenty eight overweight/obese adults (BMI>23 kg/m(2)) were included in this study and compared before and after 8 weeks of exercise program (60 min/day, 5 times in a week). The subjects, in both aerobic and resistance training, showed significant improvement in anthropometric parameters and exercise capacities including maximal oxygen uptake and muscle strength. Interestingly, the circulating irisin was significantly increased in resistance training group (p=0.002) but not in aerobic training (p=0.426) compared to control group. In addition, we found the positive correlation between change of the circulating irisin and muscle mass (r=0.432, p=0.022) and the negative correlation between change of the circulating irisin and fat mass (r=-0.407, p=0.031). In the present pilot study, we found that circulating irisin level was increased by 8 weeks of resistance training in overweight/obese adults, suggesting that resistance training could be the efficient exercise type in overweight/obese considering positive change of body composition concomitant with increase of irisin levels.
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Resistance exercise significantly increased circulating irisin levels, while aerobic exercise did not produce the same effect.
“They found that resistance exercise significantly increased circulating irisin levels, while aerobic exercise did not produce the same effect.”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [92]
Resistance exercise specifically influences lipid metabolism in the liver through the action of irisin.
“This suggests that resistance exercise specifically influences lipid metabolism in the liver through the action of irisin (92).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [92]
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References 20 · Cited by 141
- Authors
- KIM, H.-J., LEE, H.-J., SO, B., SON, J. S., YOON, D., & SONG, W.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- SONG, W.
- Venue
- Physiological Research
- Published
- 2016-04-15
- Volume
- 65
- Issue
- 2
- Pages
- 271-279
- ISSN
- 0862-8408 (ISSN-L)
- 1802-9973
- OpenAlex
- W2272142318
- Cited by
- 141
- References
- 20
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 12 · 2023: 16 · 2022: 20 · 2021: 21 · 2020: 19 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 5
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Physiological Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Research Foundation (NRF-2013M3A9D5072550, 2013M3A9D5072550)
- Ministry of Science, ICT and Future Planning (NRF‐2013M3A9D5072550, MEST 2011‐0030135, 2013M3A9D5072550, NRF‐2013M3A9B6046417)
- National Research Foundation of Korea (2011-0030135, 2013M3A9B6046417, NRF-2014R1A1A2058645, MEST 2011-0030135, NRF-2013M3A9B6046417, NRF-2013M3A9D 5072550, 2014R1A1A2058645, 2013M3A9D5072550)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- irisin, myokines, aerobic exercise, resistance training, body composition, overweight, obesity, fat mass, muscle mass, exercise capacity, VO2max, muscle strength
- MeSH terms
- Adult, Body Composition, Female, Fibronectins, Humans, Male, Obesity, Pilot Projects, Biomarkers, Exercise, Treatment Outcome, Overweight, Resistance Training
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