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Lost in Translation: The Gap in Scientific Advancements and Clinical Application

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Fernandez-Moure, Joseph S.·2016·Frontiers in Bioengineering and Biotechnology

DOI 10.3389/fbioe.2016.00043PMC PMC4891347

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Abstract

The evolution of medicine and medical technology hinges on the successful translation of basic science research from the bench to clinical implementation at the bedside. Out of the increasing need to facilitate the transfer of scientific knowledge to patients, translational research has emerged. Significant leaps in improving global health, such as antibiotics, vaccinations, and cancer therapies, have all seen successes under this paradigm, yet today, it has become increasingly difficult to realize this ideal scenario. As hospital revenue demand increases, and financial support declines, clinician-protected research time has been limited. Researchers, likewise, have been forced to abandon time- and resource-consuming translational research to focus on publication-generating work to maintain funding and professional advancement. Compared to the surge in scientific innovation and new fields of science, realization of transformational scientific findings in device development and materials sciences has significantly lagged behind. Herein, we describe: how the current scientific paradigm struggles in the new health-care landscape; the obstacles met by translational researchers; and solutions, both public and private, to overcoming those obstacles. We must rethink the old dogma of academia and reinvent the traditional pathways of research in order to truly impact the health-care arena and ultimately those that matter most: the patient.

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Figure 1 Operational challenges for translational research and medicine. Adapted from Blumberg et al. Harvard Catalyst Website (https://catalyst.harvard.edu/). Translational research is an iterative, dynamic, and layered process with several obstacles that must be negotiated (top). These layers include T0, identification of clinical problem followed by preclinical and optimization studies to define material candidates for compound synthesis or cellular mechanisms for intervention; T1, initial Phase I studies in humans that aim to demonstrate proof of concept and safety; T2, Phase II and III clinical trials that allowed for incremental and sequential evaluations and approvals prior to implementation; T3, post-marketing surveillance trials, conducted after the device has been in the market, are used to determine long term efficacy, impact on quality of life, and comparison to other similar devices; and T4, outcomes research to determine the impact of effectiveness intervening on patients in the general community, cost-effectiveness compared to equivalent technologies. Valley of death (red) comprises research related to the T0, T1, and T2 stages (Blumberg et al., 2012).CC BY · PubMed Central

Figure 2 Valleys of death. The “valleys of death” concept is used to describe situations where technology failed to reach clinical implementation. Termination of studies in Valley 1 when a technology has shown efficacy, yet is unable to obtain financing to take it to commercialization and human trials. Termination of studies in Valley 2 is due to a rapid decline of funding during the costly human trial phase and occurs during the stage in-licensed technology becomes an actual revenue-generating product.CC BY · PubMed Central

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A New Initiative on Precision Medicine
Collins, F. S., & Varmus, H. (2015) · New England Journal of Medicine · doi:10.1056/nejmp1500523 · Cited by 5,202
The growth of patenting and licensing by U.S. universities: an assessment of the effects of the Bayh–Dole act of 1980
Mowery, D. C., Nelson, R. R., Sampat, B. N., & Ziedonis, A. A. (2001) · Research Policy · doi:10.1016/s0048-7333(99)00100-6 · Cited by 1,425
Epidemiology and cost of ventral hernia repair: making the case for hernia research
Poulose, B. K., Shelton, J., Phillips, S., Moore, D., Nealon, W., Penson, D., Beck, W., & Holzman, M. D. (2012) · Hernia · doi:10.1007/s10029-011-0879-9 · Cited by 914
Star scientists and institutional transformation: Patterns of invention and innovation in the formation of the biotechnology industry
Zucker, L. G., & Darby, M. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.12709 · Cited by 770
Challenges and opportunities facing medical education.
Densen, P. (2011) · PubMed Central · Cited by 485
Organizational and institutional influences on creativity in scientific research
Heinze, T., Philip Shapira, A., Rogers, J. D., & Senker, J. M. (2009) · Research Policy · doi:10.1016/j.respol.2009.01.014 · Cited by 369
The Flexner Report and the Standardization of American Medical Education
Beck, A. H. (2004) · JAMA · doi:10.1001/jama.291.17.2139 · Cited by 340
Statins for the Primary Prevention of Cardiovascular Events in Women With Elevated High-Sensitivity C-Reactive Protein or Dyslipidemia: Results From the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and Meta-Analysis of Women From Primary Prevention Trials
Mora, S., Glynn, R. J., Hsia, J. A., MacFadyen, J. G., Genest, J. J., & Ridker, P. M. (2010) · Circulation · doi:10.1161/circulationaha.109.906479 · Cited by 331
Use of marlex mesh in the repair of incisional hernias.
USHER, F. C., Ochsner, J. L., & Ll, T. (1958) · PubMed · Cited by 310
Translational strategies and challenges in regenerative medicine
Dimmeler, S., Ding, S., Rando, T. A., & Trounson, A. (2014) · Nature Medicine · doi:10.1038/nm.3627 · Cited by 179

Show all 22 references

Research works printed but not linked: 2

Fuller, 1982, Critical Path
Schacht, 2000, Patent Ownership and Federal Research and Development (R & D): A Discussion on the Bayh-Dole Act and the Stevenson-Wydler Act

Lost in translation: the valley of death across preclinical and clinical divide – identification of problems and overcoming obstacles
Seyhan, A. A. (2019) · Translational Medicine Communications · doi:10.1186/s41231-019-0050-7 · Cited by 791
A critical review of multifunctional titanium surfaces: New frontiers for improving osseointegration and host response, avoiding bacteria contamination
Spriano, S., Yamaguchi, S., Baino, F., & Ferraris, S. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.08.013 · Cited by 406
Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction
Myung, Y., de Sá, A. G. C., & Ascher, D. B. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae254 · Cited by 401
Bioactive Glasses: Sprouting Angiogenesis in Tissue Engineering
Kargozar, S., Baino, F., Hamzehlou, S., Hill, R. G., & Mozafari, M. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.12.003 · Cited by 354
Mesoporous bioactive glasses: Promising platforms for antibacterial strategies
Kargozar, S., Montazerian, M., Hamzehlou, S., Kim, H., & Baino, F. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.09.052 · Cited by 257
Flow behavior prior to crosslinking: The need for precursor rheology for placement of hydrogels in medical applications and for 3D bioprinting
Townsend, J. M., Beck, E. C., Gehrke, S. H., Berkland, C. J., & Detamore, M. S. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.01.003 · Cited by 226
Internet of medical things: A systematic review
Huang, C., Wang, J., Wang‎, S., & Zhang, Y. (2023) · Neurocomputing · doi:10.1016/j.neucom.2023.126719 · Cited by 199
Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare
Jia, Z., Xu, X., Zhu, D., & Zheng, Y. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101072 · Cited by 176
Brief Overview of Approaches and Challenges in New Antibiotic Development: A Focus On Drug Repurposing
Boyd, N. K., Teng, C., & Frei, C. R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.684515 · Cited by 182
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Laubach, M., Hildebrand, F., Suresh, S., Wagels, M., Kobbe, P., Gilbert, F., Kneser, U., Holzapfel, B. M., & Hutmacher, D. W. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14070341 · Cited by 141
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O’Donnell, B. T., Ives, C., Mohiuddin, O. A., & Bunnell, B. A. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00095 · Cited by 88
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Kargozar, S., Mozafari, M., Hamzehlou, S., Milan, P. B., Kim, H., & Baino, F. (2019) · Applied Sciences · doi:10.3390/app9010174 · Cited by 81
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Chan, W. W., Yeo, D., Tan, V., Singh, S., Choudhury, D., & Naing, M. W. (2020) · Bioengineering · doi:10.3390/bioengineering7030066 · Cited by 56
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Background
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Authors: Fernandez-Moure, J. S.
Affiliations: Houston Methodist (US)
Corresponding author: Fernandez-Moure, Joseph S.
ORCID: Fernandez-Moure, Joseph S.
Venue: Frontiers in Bioengineering and Biotechnology
Publisher: Frontiers Media SA
Published: 2016-06-03
Volume: 4
Pages: 43-43
ISSN: 2296-4185 (ISSN-L)
DOI: 10.3389/fbioe.2016.00043
PMC: PMC4891347
OpenAlex: W2460727754
Cited by: 127
References: 22
Citations by year: 2026: 15 · 2025: 17 · 2024: 21 · 2023: 16 · 2022: 12 · 2021: 11 · 2020: 7 · 2019: 12 · 2018: 11 · 2017: 3 · 2016: 2
FWCI: 9.26
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
Social Sciences › Arts and Humanities › History and Philosophy of Science › Interdisciplinary Research and Collaboration
Social Sciences › Business, Management and Accounting › Management of Technology and Innovation › Research, Science, and Academia
Keywords: translational research, clinical application of research, research funding, medical device development, health care financing

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Lost in Translation: The Gap in Scientific Advancements and Clinical Application

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