In vitro Liver Zonation of Primary Rat Hepatocytes
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In contrast to previous studies, zonation in this device is naturally generated by high cell densities and the corresponding oxygen and nutrient utilization along the flow path.
“Importantly, in contrast to previous studies [12] , zonation in this device is naturally generated by high cell densities and the corresponding oxygen and nutrient utilization along the flow path.”
From 3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation (2023) · cites this paper as [12]
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Cites
Drug-Induced Acute Liver Failure: Results of a U.S. Multicenter, Prospective Study
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Microfabrication of human organs-on-chips
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Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes
Kang, Y. B., Eo, J., Mert, S., Yarmush, M. L., & Usta, O. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-27179-6 · Cited by 122 · see citing works
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Cited by
Sorted by citations
Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery
Fu, J., Qiu, H., & Tan, C. S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041300 · Cited by 42 · see citing works
Wesseler, M. F., Taebnia, N., Harrison, S., Youhanna, S., Preiss, L. C., Kemas, A. M., Vegvari, A., Mokry, J., Sullivan, G. J., Lauschke, V. M., et al. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.09.022 · Cited by 39 · see citing works
- Authors
- Tomlinson, L., Hyndman, L., Firman, J. W., Bentley, R., Kyffin, J. A., Webb, S. D., McGinty, S., & Sharma, P.
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2019-02-18
- Volume
- 7
- ISSN
- 2296-4185
- PMC
- PMC6387900
- Cited by
- 36
- References
- 3
- Funders
- University of Liverpool
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- Engineering and Physical Sciences Research Council (EP/M506539/1, EPM508056/1)
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