Cited by 103Mesenchymal stem cell researchParkinson's Disease Mechanisms and TreatmentsNerve injury and regeneration

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Bone Marrow Mesenchymal Stem Cells' Secretome Exerts Neuroprotective Effects in a Parkinson's Disease Rat Model

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Mendes-Pinheiro, Bárbara, Anjo, Sandra I., Manadas, Bruno, Da Silva, Jorge D., Marote, Ana, Behie, Leo A., Teixeira, Fábio G., Salgado, António J.·2019·Frontiers in Bioengineering and Biotechnology

DOI 10.3389/fbioe.2019.00294PMC PMC6838134

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Abstract

Parkinson’s disease (PD) is characterized by a selective loss of dopamine (DA) neurons in the human midbrain causing motor dysfunctions. The exact mechanism behind dopaminergic cell death is still not completely understood and, so far, no cure or neuroprotective treatment for PD is available. Recent studies have brought attention to the wide array of bioactive molecules produced by mesenchymal stem cells (MSCs), generally referred to as the secretome. Herein, we evaluated whether human MSCs-bone marrow derived (hBMSCs) secretome would be beneficial in a PD pre-clinical model, when compared directly with cell transplantation of hBMSCs alone. We used a 6-hydroxydpomanie (6-OHDA) rat PD model, and motor behavior was evaluated at different time points after treatments (1, 4 and 7 weeks). The impact of the treatments in the recovery of DA neurons was estimated by determining TH-positive neuronal densities in the substantia nigra and fibers in the striatum, respectively, at the end of the behavioral characterization. Furthermore, we determined the effect of the hBMSCs secretome on the neuronal survival of human neural progenitors in vitro, and characterized the secretome through proteomic-based approaches. This work demonstrates that the injection of hBMSCs secretome potentiated the histological recovery of DA neurons, when compared to transplantation of hBMSCs themselves, a fact that probably explains the improved behavioral performance of secretome-injected animals in the staircase test. Moreover, we observed that hBMSCs secretome induces higher levels of in vitro neuronal differentiation. Finally, the proteomic analysis revealed that hBMSCs secrete a variety of important exosome-related molecules such as those related with the ubiquitin-proteasome and histone systems. Overall, this work provided important insights on the potential use of hBMSCs secretome as a therapeutic tool for PD, and further confirms the importance of the secreted molecules rather than the transplantation of hBMSCs for the observed positive effects. These could be likely through normalization of defective processes in PD, namely proteostasis or altered gene transcription, which lately can lead to neuroprotective effects.

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Authors: Mendes-Pinheiro, B., Anjo, S. I., Manadas, B., Da Silva, J. D., Marote, A., Behie, L. A., Teixeira, F. G., & Salgado, A. J.
Affiliations: University of Minho (PT)
Centro de Neurociências e Biologia Celular (PT)
University of Calgary (CA)
Corresponding author: Salgado, António J.
ORCID: Mendes-Pinheiro, Bárbara
Anjo, Sandra I.
Manadas, Bruno
Marote, Ana
Behie, Leo A.
Teixeira, Fábio G.
Salgado, António J.
Venue: Frontiers in Bioengineering and Biotechnology
Publisher: Frontiers Media SA
Published: 2019-11-01
Volume: 7
Pages: 294-294
ISSN: 2296-4185 (ISSN-L)
DOI: 10.3389/fbioe.2019.00294
PMC: PMC6838134
OpenAlex: W2988721710
Cited by: 103
References: 69
Citations by year: 2026: 4 · 2025: 17 · 2024: 9 · 2023: 15 · 2022: 22 · 2021: 19 · 2020: 15 · 2019: 1
FWCI: 7.81
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Universidade do Minho
Fundação para a Ciência e a Tecnologia (01-0145, POCI-01-0145, POCI- 01-0145-FEDER-029751, POCI-01- 0145-FEDER-016428., POCI‐01‐0145‐FEDER‐007038, SFRH/BPD/118408/2016, POCI-01-0145-FEDER-, POCI-01-0145-FEDER-032619, IF/00111, IF/00111/2013, PTDC/NEU-SCC/7051/2014, SFRH/BD/120124/2016, POCI-01-0145-FEDER-029311, POCI-01-, POCI-01-0145-FEDER-016795, SAICTPAC/0010/2015, SFRH/BD/120124/)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: Parkinson's disease, bone marrow mesenchymal stem cells, secretome, neuroprotection, dopaminergic neuron loss, cell transplantation, exosomes, proteomics, neuronal differentiation, substantia nigra, striatum, ubiquitin-proteasome system, proteostasis, staircase test

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Bone Marrow Mesenchymal Stem Cells' Secretome Exerts Neuroprotective Effects in a Parkinson's Disease Rat Model

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