Harnessing genetic engineering to drive economic bioproduct production in algae
Open accessAbstract
Our reliance on agriculture for sustenance, healthcare, and resources has been essential since the dawn of civilization. However, traditional agricultural practices are no longer adequate to meet the demands of a burgeoning population amidst climate-driven agricultural challenges. Microalgae emerge as a beacon of hope, offering a sustainable and renewable source of food, animal feed, and energy. Their rapid growth rates, adaptability to non-arable land and non-potable water, and diverse bioproduct range, encompassing biofuels and nutraceuticals, position them as a cornerstone of future resource management. Furthermore, microalgae's ability to capture carbon aligns with environmental conservation goals. While microalgae offers significant benefits, obstacles in cost-effective biomass production persist, which curtails broader application. This review examines microalgae compared to other host platforms, highlighting current innovative approaches aimed at overcoming existing barriers. These approaches include a range of techniques, from gene editing, synthetic promoters, and mutagenesis to selective breeding and metabolic engineering through transcription factors.
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Microalgae can be grown on non-arable land and utilise non-potable or saline water, avoiding competition with traditional crops for critical resources.
“They can be grown on non-arable land and utilise non-potable or saline water, thereby avoiding competition with traditional crops for critical resources [121,124].”
From Microalgae Bioactives for Functional Food Innovation and Health Promotion (2025) · cites this paper as [124]
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References 252 · Cited by 60
- Authors
- Gupta, A., Kang, K., Pathania, R., Saxton, L., Saucedo, B., Malik, A., Torres-Tiji, Y., Diaz, C. J., Dutra Molino, J. V., & Mayfield, S. P.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Mayfield, Stephen P.
- ORCID
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2024-01-29
- Volume
- 12
- Pages
- 1350722-1350722
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC10859422
- OpenAlex
- W4391320711
- Cited by
- 60
- References
- 252
- Citations by year
- 2026: 19 · 2025: 29 · 2024: 12
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Energy (DEEE0009671)
- University of California, San Diego
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- microalgae, genetic engineering, metabolic engineering, genome editing, synthetic promoters, mutagenesis, selective breeding, transcription factors, biofuels, nutraceuticals, CO2 capture, biomass production
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