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Cited by 127Bacterial Genetics and BiotechnologyHeavy Metal Exposure and ToxicityIron Metabolism and Disorders

Manganese acquisition and homeostasis at the host-pathogen interface

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Lisher, John P., Giedroc, David P.·2013·Frontiers in Cellular and Infection Microbiology
DOI 10.3389/fcimb.2013.00091PMC PMC3851752
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Abstract

Pathogenic bacteria acquire transition metals for cell viability and persistence of infection in competition with host nutritional defenses. The human host employs a variety of mechanisms to stress the invading pathogen with both cytotoxic metal ions and oxidative and nitrosative insults while withholding essential transition metals from the bacterium. For example, the S100 family protein calprotectin (CP) found in neutrophils is a calcium-activated chelator of extracellular Mn and Zn and is found in tissue abscesses at sites of infection by Staphylococcus aureus. In an adaptive response, bacteria have evolved systems to acquire the metals in the face of this competition while effluxing excess or toxic metals to maintain a bioavailability of transition metals that is consistent with a particular inorganic "fingerprint" under the prevailing conditions. This review highlights recent biological, chemical and structural studies focused on manganese (Mn) acquisition and homeostasis and connects this process to oxidative stress resistance and iron (Fe) availability that operates at the human host-pathogen interface.

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  • The overall manganese quota varies widely, with the Mn:Fe ratio varying by more than 6 orders of magnitude.

    “The overall manganese quota varies widely, with the ratio of Mn:Fe ratio varying by >6 orders of magnitude.97”

    From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [97]

  • Manganese is a critical element for most forms of life, although levels of manganese are exceedingly low in some bacteria.

    “Manganese (Mn) is a critical element for most forms of life, although levels of manganese are exceedingly low in some bacteria.97”

    From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [97]

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Cited by

Sorted by citations

Authors
Lisher, J. P., & Giedroc, D. P.
Affiliations
Indiana University Bloomington (US)
Corresponding author
Giedroc, David P.
ORCID
Giedroc, David P.
Venue
Frontiers in Cellular and Infection Microbiology
Publisher
Frontiers Media SA
Published
2013
Volume
3
Pages
91-91
ISSN
2235-2988 (ISSN-L)
DOI
10.3389/fcimb.2013.00091
PMC
PMC3851752
OpenAlex
W2061431207
Cited by
127
References
15
Citations by year
2026: 1 · 2025: 10 · 2024: 3 · 2023: 10 · 2022: 13 · 2021: 13 · 2020: 13 · 2019: 15 · 2018: 6 · 2017: 11 · 2016: 12 · 2015: 13 · 2014: 7
FWCI
1.29
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (GM042569)
  • National Institute of General Medical Sciences (R01GM042569)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
manganese homeostasis, host-pathogen interface, calprotectin, S-100 protein, Staphylococcus aureus, oxidative stress resistance, iron availability, metal efflux, neutrophils, metal chelation
MeSH terms
Bacteria, Bacterial Infections, Homeostasis, Humans, Manganese, Host-Pathogen Interactions

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