Fecal Serine Protease Profiling in Inflammatory Bowel Diseases
Open accessAbstract
Serine proteases are extensively known to play key roles in many physiological processes. However, their dysregulation is often associated to several diseases including inflammatory bowel diseases (IBD). Here, we used specific substrates to monitor fecal protease activities in a large cohort of healthy and IBD patients. Of interest, serine protease activity was 10-fold higher in IBD fecal samples compared to healthy controls. Moreover, functional analysis of these fecal proteolytic activities revealed that the most increased activities are trypsin-like, elastase-like and cathepsin G-like. We also show for the first time, an increase of proteinase 3-like activity in these samples compared to controls. Results presented here will guide further investigations to better understand the relevance of these peptidases in IBD.
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Fecal samples from patients reveal an increase in serine protease activity during inflammatory bowel disease.
“Protease activity within fecal samples from patients has been also tested and revealed an increase in serine protease activity during IBD.12”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [12]
Elevated proteolytic activity is observed in stool supernatants from inflammatory bowel disease and irritable bowel syndrome patients compared to healthy subjects.
“Elevated PA was also observed in stool supernatants from IBD and IBS patients compared to samples from healthy subjects, suggesting that enhanced PA in IBD and IBS may be due to elevations in PA from both host and microbial origin.12,13”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [12]
Enhanced proteolytic activity in inflammatory bowel disease and irritable bowel syndrome may be due to elevations from both host and microbial origin.
“suggesting that enhanced PA in IBD and IBS may be due to elevations in PA from both host and microbial origin.12,13”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [12]
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References 31 · Cited by 101
- Authors
- Jablaoui, A., Kriaa, A., Mkaouar, H., Akermi, N., Soussou, S., Wysocka, M., Wołoszyn, D., Amouri, A., Gargouri, A., Maguin, E., Lesner, A., & Rhimi, M.
- Affiliations
- AgroParisTech (FR)
- University of Gdańsk (PL)
- Hopital Universitaire Hedi Chaker (TN)
- University of Sfax (TN)
- Corresponding author
- Rhimi, Moez
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2020-02-04
- Volume
- 10
- Pages
- 21-21
- ISSN
- 2235-2988 (ISSN-L)
- PMC
- PMC7011180
- OpenAlex
- W3005480018
- Cited by
- 101
- References
- 31
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 25 · 2020: 14
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Institut National de la Recherche Agronomique
- Campus France
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- serine protease, inflammatory bowel disease, trypsin-like activity, elastase-like activity, protease substrates, gut dysbiosis
- MeSH terms
- Feces, Humans, Pancreatic Elastase, Inflammatory Bowel Diseases, Serine Proteases
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