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Strategies for combating antibiotic resistance in bacterial biofilms

Grooters, Kayla E., Ku, Jennifer C., Richter, David M., Krinock, Matthew J., Minor, Ashley, Li, Patrick, Kim, Audrey, Sawyer, Robert, Li, Yong·2024·Frontiers in Cellular and Infection Microbiology
DOI 10.3389/fcimb.2024.1352273PMC PMC10846525
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Abstract

Biofilms, which are complexes of microorganisms that adhere to surfaces and secrete protective extracellular matrices, wield substantial influence across diverse domains such as medicine, industry, and environmental science. Despite ongoing challenges posed by biofilms in clinical medicine, research in this field remains dynamic and indeterminate. This article provides a contemporary assessment of biofilms and their treatment, with a focus on recent advances, to chronicle the evolving landscape of biofilm research.

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Figure 1 Mechanism of biofilm formation. Environmental conditions lead planktonic bacteria to utilize adhesion machinery to attach to a surface. Quorum sensing between colony members drives upregulation of extracellular matrix formation and changes in metabolic function, irreversibly cementing biofilm to surface and protecting the colony from environmental hazards (e.g., antiseptics, reactive oxygen species (ROS) and antibiotics. Figure made using Biorender.com.
Figure 1 Mechanism of biofilm formation. Environmental conditions lead planktonic bacteria to utilize adhesion machinery to attach to a surface. Quorum sensing between colony members drives upregulation of extracellular matrix formation and changes in metabolic function, irreversibly cementing biofilm to surface and protecting the colony from environmental hazards (e.g., antiseptics, reactive oxygen species (ROS) and antibiotics. Figure made using Biorender.com.CC BY · PubMed Central

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Authors
Grooters, K. E., Ku, J. C., Richter, D. M., Krinock, M. J., Minor, A., Li, P., Kim, A., Sawyer, R., & Li, Y.
Venue
Frontiers in Cellular and Infection Microbiology
Publisher
Frontiers Media SA
Published
2024-01-19
Volume
14
ISSN
2235-2988
DOI
10.3389/fcimb.2024.1352273
PMC
PMC10846525
Cited by
156
References
0
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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CoChat. (2026). Citation check: Strategies for combating antibiotic resistance in bacterial biofilms. https://app.cochat.ai/papers/10.3389/fcimb.2024.1352273
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Grooters, K. E., Ku, J. C., Richter, D. M., Krinock, M. J., Minor, A., Li, P., Kim, A., Sawyer, R., & Li, Y. (2024). Strategies for combating antibiotic resistance in bacterial biofilms. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2024.1352273