RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication
Open accessAbstract
Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promoting inflammatory reactions. The receptor for advanced glycation end-products (RAGE) is a member of PRRs and a proinflammatory molecular device that mediates danger signals to the body. The expression of RAGE is observed in adipocytes as well as immune cells, endothelial cells, and pancreatic β cells under certain conditions. It has been reported that RAGE is implicated in adipocyte hypertrophy and insulin resistance. RAGE-mediated regulation of adiposity and inflammation may attribute to type 2 diabetes and diabetic vascular complications.
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RAGE is not known to be related to oxytocin or oxytocin signalling.
“RAGE, a member of the immunoglobulin superfamily of pattern recognition receptors, is not known to be related to oxytocin or oxytocin signalling22–33.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [28]
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References 14 · Cited by 99
Research works printed but not linked: 3
- [5]Yamamoto Y Yamamoto H RAGE-mediated inflammation and diabetic vascular complications. J Diabetes Invest (2011) 2: 155– 7 10.1111/j.2040-1124.2011.00125.x PMC4014911 24843476 · DOI
- [9]Yamamoto Y Yamamoto H Controlling RAGE to conquer diabetic vascular complications. J Diabetes Invest (2012) 3: 107– 14 10.1111/j.2040-1124.2011.00191.x PMC4020727 24843553 · DOI
- [20]Ueno H Koyama H Shoji T Monden M Fukumoto S Tanaka S Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mouse. Atherosclerosis (2000) 211: 431– 6 10.1016/j.atherosclerosis.2010.04.006 20435311 · DOI · Paper page
- Authors
- Yamamoto, Y., & Yamamoto, H.
- Affiliations
- Kanazawa University (JP)
- Corresponding author
- Yamamoto, Yasuhiko
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 105-105
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC3748367
- OpenAlex
- W2082229116
- Cited by
- 99
- References
- 14
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 7 · 2023: 8 · 2022: 3 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 11 · 2013: 2
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (25461335)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- receptor for advanced glycation end products, RAGE, inflammation, type 2 diabetes, diabetic vascular complications, obesity, innate immunity, pattern recognition receptors, macrophages, adipocyte hypertrophy, insulin resistance, adiposity, endothelial cells, pancreatic beta cells
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