Local Renin-Angiotensin System in the Reproductive System
Open accessAbstract
The renin-angiotensin system (RAS) is well known as regulator of electrolytes and blood pressure. Besides this function, there are numerous studies supporting the idea of a local tissue RAS. This system controls the local activity of the different RAS family members, especially of the functional proteins Angiotensin II and Angiotensin (1-7). Those antagonistically acting proteins have been described to be expressed in different organ systems including the human reproductive tract. Therefore, this local RAS has been suspected to be involved in the control and regulation of physiological and pathological conditions in the female reproduction tract. This review of the available literature summarizes the physiological influence of the RAS on the follicular development, ovarian angiogenesis, and placental- and uterine function. In addition, in the second part the role of the RAS concerning ovarian- and endometrial cancer becomes elucidated. This section includes possible novel therapeutic strategies via inhibition of RAS-mediated tumor growth and angiogenesis. Looking at a very complex system of agonistic and antagonistic tissue factors, it may be supposed that the RAS in the female reproduction tract will be of rising scientific interest in the upcoming years.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The local RAS is a complex network of precursors, peptides, enzymes and receptors involved in regulating ovarian function, oogenesis and ovarian diseases via paracrine and autocrine.
“The local RAS emphasizes a complex network of precursors, peptides, enzymes and receptors [5], which is involved in regulating ovarian function, oogenesis and ovarian diseases or abnormalities via paracrine and autocrine [6, 7].”
From Transplantation of human umbilical cord-derived mesenchymal stem cells improves age-related ovarian functional decline via regulating the local renin–angiotensin system on inflammation and oxidative stress (2024) · cites this paper as [6]
The Introduction (page unavailable) describes local RAS peptides, enzymes and receptors and links them to follicle maturation and other reproductive processes. The sections on ovary and follicular development and ovarian cancer discuss oocyte maturation and ovarian pathology. The copy does not specify paracrine and autocrine mechanisms for these effects, and its Conclusion cautions that many functional conclusions remain speculative. (LLM, conf=0.83)
Experimental — accuracy not yet measuredThere is a local RAS in the human ovary that plays a key role.
“Recently, it has been found that there is a local Renin–angiotensin system (RAS) in human ovary and it plays a key role.”
From Transplantation of human umbilical cord-derived mesenchymal stem cells improves age-related ovarian functional decline via regulating the local renin–angiotensin system on inflammation and oxidative stress (2024) · cites this paper as [6]
The “Ovary and follicular development” section explicitly says a local RAS is present in the adult ovary and that its components have been found in the human ovary. The Conclusion considers it potentially important for reproductive regulation, but cautions that most functional conclusions remain speculative; “plays a key role” states that role more definitively than the review does. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 93 · Cited by 91
- Authors
- Herr, D., Bekes, I., & Wulff, C.
- Affiliations
- Saarland University (DE)
- University Hospital Ulm (DE)
- Corresponding author
- Herr, Daniel
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 150-150
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC3798827
- OpenAlex
- W2014091868
- Cited by
- 91
- References
- 93
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 5 · 2020: 14 · 2019: 1 · 2018: 10 · 2017: 6 · 2016: 3 · 2015: 10 · 2014: 7
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- local renin-angiotensin system, female reproductive tract, angiotensin II, angiotensin-(1-7), folliculogenesis, ovarian angiogenesis, placental function, uterine function, endometrial cancer, ovarian cancer, RAS inhibition, tumor angiogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
