Early-Life Stress, HPA Axis Adaptation, and Mechanisms Contributing to Later Health Outcomes

Maniam, Jayanthi; Antoniadis, Christopher; Morris, Margaret J.

doi:10.3389/fendo.2014.00073

Early-Life Stress, HPA Axis Adaptation, and Mechanisms Contributing to Later Health Outcomes

Stress activates the hypothalamic–pituitary–adrenal (HPA) axis, which then modulates the degree of adaptation and response to a later stressor. It is known that early-life stress can impact on later health but less is known about how early-life stress impairs HPA axis activity, contributing to ma…