The DOI matches its Crossref record; 222 of the 222 references it cites were found in a registry or an index.
Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases
Open accessAbstract
Cardiometabolic diseases encompass those affecting the heart and vasculature as well as other metabolic problems, such as insulin resistance, diabetes, and non-alcoholic fatty liver disease. These diseases tend to have common risk factors, one of which is impaired adiponectin action. This may be due to reduced bioavailability of the hormone or resistance to its effects on target tissues. A strong negative correlation between adiponectin levels and cardiometabolic diseases has been well-documented and research shown that adiponectin has cardioprotective, insulin sensitizing and direct beneficial metabolic effects. Thus, therapeutic approaches to enhance adiponectin action are widely considered to be desirable. The complexity of adiponectin structure and function has so far made progress in this area less than ideal. In this article we will review the effects and mechanism of action of adiponectin on cardiometabolic tissues, identify scenarios where enhancing adiponectin action would be of clinical value and finally discuss approaches via which this can be achieved.
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“Several short peptides and small molecules have been identified today to target AdipoRs and mimic some of ApN effects.”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [120]
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“These receptor agonists can induce similar downstream signaling cascades to ApN, such as AMPK, p38MAPK, and PPARα [120] (Table 1).”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [120]
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Abou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72
Yoon, G., Shah, S. A., Ali, T., & Kim, M. O. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0847-1 · Cited by 34
Metadata
- Authors
- Liu, Y., Vu, V., & Sweeney, G.
- Affiliations
- York University (CA)
- Corresponding author
- Liu, Ying
- Sweeney, Gary
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-12-11
- Volume
- 10
- Pages
- 842-842
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6918867
- OpenAlex
- W2995030404
- Cited by
- 69
- References
- 222
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 12 · 2023: 14 · 2022: 8 · 2021: 15 · 2020: 7
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adiponectin, cardiometabolic disease, insulin resistance, diabetes mellitus, non-alcoholic fatty liver disease, adiponectin resistance, cardioprotection, insulin sensitization
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