Book review: The Epigenetics Revolution
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Both maternal and paternal nutritional environments before and during conception can profoundly influence offspring metabolic programming through heritable epigenetic mechanisms.
“Together, these findings demonstrate that both maternal and paternal nutritional environments before and during conception can profoundly influence offspring metabolic programming through heritable epigenetic mechanisms.”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [169]
In the book-review section (page not specified), the review discusses heritable epigenetic modifications and says the Dutch famine affected offspring health; it also mentions a correlation with obesity. It does not address both maternal and paternal nutritional environments, the timing before and during conception, or offspring metabolic programming specifically. (LLM, conf=0.86)
Experimental — accuracy not yet measuredParental health and diet, not only during pregnancy but also prior to conception, play a crucial role in shaping disease susceptibility across generations.
“The concept of transgenerational inheritance thus expands the traditional view of fetal programming, emphasizing that parental health and diet—not only during pregnancy but also prior to conception—play a crucial role in shaping disease susceptibility across generations [73,169,175,177,178,179].”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [169]
The review’s discussion of Chapter 6 (page not specified) says environmental events such as the Dutch famine affect offspring health outcomes. It does not specify parental health or diet before conception, nor establish effects across multiple generations; it also notes limits on the inheritance of epigenetic modifications. (LLM, conf=0.83)
Experimental — accuracy not yet measuredStudies on grandchildren of women exposed to famine in utero showed that grandsons of women malnourished during early pregnancy tended to have higher birth weights, while exposure in late pregnancy did not affect birth weight.
“Studies on the grandchildren of women exposed to famine in utero showed that grandsons of women malnourished during early pregnancy tended to have higher birth weights, while exposure in late pregnancy did not affect birth weight [169,170,171,172].”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [169]
The book review’s discussion of Chapter 6 says the Dutch famine affected offspring health outcomes, supporting the broad idea of effects across generations. It does not report birth weights in grandsons or distinguish exposure in early versus late pregnancy; searches for those details found no passage in our copy. (LLM, conf=0.78)
Experimental — accuracy not yet measuredBoth maternal undernutrition and overnutrition can induce heritable epigenetic modifications affecting energy metabolism, thereby perpetuating metabolic dysfunction across generations.
“Together, these findings provide compelling evidence that both maternal undernutrition and overnutrition can induce heritable epigenetic modifications affecting energy metabolism, thereby perpetuating metabolic dysfunction across generations.”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [169]
The book review’s discussion of Chapter 6 describes heritable epigenetic modifications and says the Dutch famine affected offspring health; it also mentions a correlation between the famine and obesity. It does not address maternal overnutrition, demonstrate changes in energy metabolism, or establish metabolic dysfunction across multiple generations. The review also notes that embryonic reprogramming prevents many modifications from being passed on. (LLM, conf=0.85)
Experimental — accuracy not yet measured
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Cited by
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Schiera, G., Macajone, G., Volpes, S., Greco, L., Di Liegro, C. M., Serio, G., Caradonna, F., & Naselli, F. (2026) · Cells · doi:10.3390/cells15040366 · Cited by 8 · see citing works
- Authors
- Roe, C., & May, L.
- Affiliations
- Brighton and Sussex Medical School (GB)
- Corresponding author
- Roe, Cieron
- ORCID
- Roe, Cieron
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2015-08-13
- Volume
- 6
- ISSN
- 1664-8021 (ISSN-L)
- PMC
- PMC4534858
- OpenAlex
- W1616590541
- Cited by
- 1
- References
- 0
- Citations by year
- 2019: 1
- Type
- book review
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- epigenetics
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