Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice
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The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated animal was performed at the time when half of the population had already died. As a result, the maximum lifespan (MLS) increased by 28 ± 5%, and the survival time from the beginning of the experiment increased 2.8 ± 0.3-fold. The chimerism of the BM 6 months after the transplantation was 28%.
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Transplantation of young bone marrow preserves synaptic connections and cognitive manifestations in aged mice, increasing maximum lifespan by 30%.
“transplantation of young bone marrow plays a positive role in preserving synaptic connections and cognitive manifestations in aged mice,454 increasing the maximum lifespan by 30%.455”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [455]
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References 26 · Cited by 24
- Authors
- Kovina, M. V., Karnaukhov, A. V., Krasheninnikov, M. E., Kovin, A. L., Gazheev, S. T., Sergievich, L. A., Karnaukhova, E. V., Bogdanenko, E. V., Balyasin, M. V., Khodarovich, Y. M., Dyuzheva, T. G., & Lyundup, A. V.
- Affiliations
- Sechenov University (RU)
- Russian Academy of Sciences (RU)
- Corresponding author
- Kovina, Marina V.
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2019-04-12
- Volume
- 10
- Pages
- 310-310
- ISSN
- 1664-8021 (ISSN-L)
- PMC
- PMC6473025
- OpenAlex
- W2938394743
- Cited by
- 24
- References
- 26
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 1
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- bone marrow transplantation, nonmyeloablative transplantation, syngeneic transplantation, maximum lifespan, aging, bone marrow chimerism, aged mice, survival time, hematopoietic stem cells
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