Functional Significance of CD57 Expression on Human NK Cells and Relevance to Disease
Open accessAbstract
Historically, human NK cells have been identified as CD3(-)CD56(+)CD16(±) lymphocytes. More recently it has been established that CD57 expression defines functionally discrete sub-populations of NK cells. On T cells, CD57 expression has been regarded as a marker of terminal differentiation and (perhaps wrongly) of anergy and senescence. Similarly, CD57 expression seems to identify the final stages of peripheral NK cell maturation; its expression increases with age and is associated with chronic infections, particularly human cytomegalovirus infection. However, CD57(+) NK cells are highly cytotoxic and their presence seems to be beneficial in a number of non-communicable diseases. The purpose of this article is to review our current understanding of CD57 expression as a marker of NK cell function and disease prognosis, as well as to outline areas for further research.
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CD57+CD3- NK cells are terminally differentiated, have higher cytolytic capabilities, act as innate immune regulators, are less responsive to cytokines, and are connected to autoimmunity and immunodeficiency.
“These NK cells are functionally different than traditional, CD56 + NK cells-they are terminally differentiated and have higher cytolytic capabilities, and generally act as innate immune regulators despite being less responsive to cytokines and connected to autoimmunity and immunodeficiency (Lopez-Verges et al, 2010;Nielsen et al, 2013).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Nielsen et al, 2013
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References 135 · Cited by 282
Research works printed but not linked: 1
- [77]O’Gorman M Smith R Garrison A Shamiyeh E Pachman L Lymphocyte subsets in peripheral blood from newly diagnosed, untreated patients with juvenile dermatomyositis (JDM) are associated with disease activity scores (DAS). Arthritis Rheum (2002) 46(9): S490– 490
- Authors
- Nielsen, C. M., White, M. J., Goodier, M. R., & Riley, E. M.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- Corresponding author
- Riley, Eleanor M.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 422-422
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC3856678
- OpenAlex
- W2110232771
- Cited by
- 282
- References
- 135
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 31 · 2023: 25 · 2022: 31 · 2021: 27 · 2020: 26 · 2019: 21 · 2018: 27 · 2017: 24 · 2016: 11 · 2015: 14 · 2014: 9 · 2013: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Medical Research Council (MR/J003999/1, G1000808)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- CD57, natural killer cells, NK cell maturation, cytotoxicity, human cytomegalovirus infection, chronic infection, aging, non-communicable diseases, disease prognosis, CD56, CD16
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