DAMP-Mediated Activation of NLRP3-Inflammasome in Brain Sterile Inflammation: The Fine Line between Healing and Neurodegeneration
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FRONTIERS COMMENTARY article Front. Immunol., 17 March 2014 Volume 5 - 2014 | https://doi.org/10.3389/fimmu.2014.00099
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Neuronal damage is an important triggering factor for NOX activation in microglia, likely mediated by DAMPs originating from neurones in both acute injury and chronic neuroinflammation.
“Neuronal damage is an important triggering factor for NOX activation in microglia, likely mediated by DAMPs originating from neurones in both acute injury and chronic neuroinflammation [89,90].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [90]
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References 9 · Cited by 55
- Authors
- Rubartelli, A.
- Affiliations
- Ospedale Policlinico San Martino (IT)
- Corresponding author
- Rubartelli, Anna
- ORCID
- Rubartelli, Anna
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2014-03-17
- Volume
- 5
- Pages
- 99-99
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC3956122
- OpenAlex
- W2126200883
- Cited by
- 55
- References
- 9
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 5
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- damage-associated molecular patterns, NLRP3 inflammasome, sterile inflammation, neuroinflammation, neurodegeneration, neuroprotection
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