The DOI matches its Crossref record; 398 of the 398 references it cites were found in a registry or an index.
Pathogenesis of Systemic Sclerosis
Open accessAbstract
Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts), and components of the innate and adaptive immune systems. Clinical and pathologic manifestations of SSc are the result of: (1) innate/adaptive immune system abnormalities leading to production of autoantibodies and cell-mediated autoimmunity, (2) microvascular endothelial cell/small vessel fibroproliferative vasculopathy, and (3) fibroblast dysfunction generating excessive accumulation of collagen and other matrix components in skin and internal organs. All three of these processes interact and affect each other. The disease is heterogeneous in its clinical presentation that likely reflects different genetic or triggering factor (i.e., infection or environmental toxin) influences on the immune system, vasculature, and connective tissue cells. The roles played by other ubiquitous molecular entities (such as lysophospholipids, endocannabinoids, and their diverse receptors and vitamin D) in influencing the immune system, vasculature, and connective tissue cells are just beginning to be realized and studied and may provide insights into new therapeutic approaches to treat SSc.
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1 retracted
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
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Chen, W., Mook, R. A., Premont, R. T., & Wang, J. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2017.04.001 · Cited by 444
Mendoza, F. A., Piera‐Velazquez, S., Farber, J. L., Feghali‐Bostwick, C., & Jiménez, S. A. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39421 · Cited by 121
Ma, J., liu, J., Gao, D., Li, X., Zhang, Q., Lv, L., Wang, Y., Li, J., Zhu, Y., Wu, Z., et al. (2022) · Advanced Science · doi:10.1002/advs.202104192 · Cited by 53
Metadata
- Authors
- Pattanaik, D., Brown, M., Postlethwaite, B. C., & Postlethwaite, A. E.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-06-08
- Volume
- 6
- Pages
- 272-272
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W1505701939
- Cited by
- 405
- References
- 398
- FWCI
- 23.63
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pattanaik, D., Brown, M., Postlethwaite, B. C., & Postlethwaite, A. E. (2015). Pathogenesis of Systemic Sclerosis. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2015.00272
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
