The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance
Open accessAbstract
Malignant transformation of cells leads to enhanced glucose uptake and the conversion of a larger fraction of pyruvate into lactate, even under normoxic conditions; this phenomenon of aerobic glycolysis is largely known as the Warburg effect. This metabolic reprograming serves to generate biosynthetic precursors, thus facilitating the survival of rapidly proliferating malignant cells. Extracellular lactate directs the metabolic reprograming of tumor cells, thereby serving as an additional selective pressure. Besides tumor cells, stromal cells are another source of lactate production in the tumor microenvironment, whose role in both tumor growth and the antitumor immune response is the subject of intense research. In this review, we provide an integral perspective of the relationship between lactate and the overall tumor microenvironment, from lactate structure to metabolic pathways for its synthesis, receptors, signaling pathways, lactate-producing cells, lactate-responding cells, and how all contribute to the tumor outcome. We discuss the role of lactate as an immunosuppressor molecule that contributes to tumor evasion and we explore the possibility of targeting lactate metabolism for cancer treatment, as well as of using lactate as a prognostic biomarker.
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Cites
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“The question now is how do infiltrating immune cells cope with a lactate-rich microenvironment? To start with, activated immune cells are also lactate producer cells, as it has been demonstrated that, upon activation, T lymphocytes increase the expression of glucose transporters, key glycolytic enzymes, glycolysis rat…”
BackgroundBiochemistry of exercise-induced metabolic acidosis
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Cited by
The updated landscape of tumor microenvironment and drug repurposing
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Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
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The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity
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Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310
Metadata
- Authors
- Romero-Garcia, S., Moreno-Altamirano, M. M. B., Prado-Garcia, H., & Sánchez-García, F. J.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2016-02-16
- Volume
- 7
- Pages
- 52-52
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2279077379
- Cited by
- 506
- References
- 20
- FWCI
- 19.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Romero-Garcia, S., Moreno-Altamirano, M. M. B., Prado-Garcia, H., & Sánchez-García, F. J. (2016). Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2016.00052
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
