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CD56 in the Immune System: More Than a Marker for Cytotoxicity?
Open accessAbstract
Over the past years, the phenotypic and functional boundaries distinguishing the main cell subsets of the immune system have become increasingly blurred. In this respect, CD56 (also known as NCAM) is a very good example. CD56 is the archetypal phenotypic marker of natural killers cells, but can actually be expressed by many more immune cells, including alpha beta (αβ) T cells, gamma delta (γδ) T cells, dendritic cells and monocytes. Common to all these CD56-expressing cell types are strong immunostimulatory effector functions, including T helper 1 cytokine production and an efficient cytotoxic capacity. Interestingly, both numerical and functional deficiencies and phenotypic alterations of the CD56+ immune cell fraction have been reported in patients with various infectious, autoimmune or malignant diseases. In this review, we will discuss our current knowledge on the expression and function of CD56 in the hematopoietic system, both in health and disease.
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Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
Ruggeri, L., Capanni, M., Urbani, E., Perruccio, K., Shlomchik, W. D., Tosti, A., Posati, S., Rogaia, D., Frassoni, F., Aversa, F., et al. (2002) · Science · doi:10.1126/science.1068440 · Cited by 3,380
PD-1 Blockade Expands Intratumoral Memory T Cells
Ribas, A., Shin, D. S., Zaretsky, J., Frederiksen, J., Cornish, A., Avramis, E., Seja, E., Kivork, C., Siebert, J., Kaplan-Lefko, P., et al. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0210 · Cited by 405 · cited 2×
“For example, in metastatic melanoma, a distinct population of T cells with high expression of HLA-DR and CD56 increased by ninefold in patients responding to anti-PD-1 therapy (15).”
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Cited by
Normalizing and denoising protein expression data from droplet-based single cell profiling
Mulè, M. P., Martins, A. J., & Tsang, J. S. (2022) · Nature Communications · doi:10.1038/s41467-022-29356-8 · Cited by 197
Waugh, K. A., Araya, P., Pandey, A., Jordan, K. R., Smith, K. P., Granrath, R. E., Khanal, S., Butcher, E. T., Estrada, B. E., Rachubinski, A. L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.038 · Cited by 150
Spatial immune scoring system predicts hepatocellular carcinoma recurrence
Jia, G., He, P., Dai, T., Goh, D., Wang, J., Sun, M., Wee, F., Li, F., Lim, J. C. T., Hao, S., et al. (2025) · Nature · doi:10.1038/s41586-025-08668-x · Cited by 104
Methods of Controlling Invasive Fungal Infections Using CD8+ T Cells
Kumaresan, P. R., da Silva, T. A., & Kontoyiannis, D. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01939 · Cited by 85
Identification of human exTreg cells as CD16+CD56+ cytotoxic CD4+ T cells
Freuchet, A., Roy, P., Armstrong, S. S., Oliaeimotlagh, M., Kumar, S., Orecchioni, M., Ali, A. J., Khan, A., Makings, J., Lyu, Q., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01589-9 · Cited by 72
Metadata
- Authors
- Van Acker, H. H., Capsomidis, A., Smits, E. L., & Van Tendeloo, V. F.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2017-07-24
- Volume
- 8
- Pages
- 892-892
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2735932253
- Cited by
- 388
- References
- 2
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- Van Acker, H. H., Capsomidis, A., Smits, E. L., & Van Tendeloo, V. F. (2017). CD56 in the Immune System: More Than a Marker for Cytotoxicity? Frontiers in Immunology. https://doi.org/10.3389/fimmu.2017.00892
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
