The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Vitamin D Is Required for ILC3 Derived IL-22 and Protection From Citrobacter rodentium Infection
Open accessAbstract
Citrobacter rodentium is a gastrointestinal infection that requires early IL-22 from group 3 innate lymphoid cells (ILC3) for resistance. The role of vitamin D in the clearance of C. rodentium infection was tested in vitamin D sufficient (D+) and vitamin D deficient (D-) wildtype (WT) and Cyp27B1 (Cyp) KO mice (unable to produce the high affinity vitamin D ligand 1,25(OH)2D, 1,25D). Feeding Cyp KO mice D- diets reduced vitamin D levels and prevented synthesis of 1,25D. D- (WT and Cyp KO) mice had fewer ILC3 cells and less IL-22 than D+ mice. D- Cyp KO mice developed a severe infection that resulted in the lethality of the mice by d14 post-infection. T and B cell deficient D- Rag KO mice also developed a severe and lethal infection with C. rodentium compared to D+ Rag KO mice. D- WT mice survived the infection but took significantly longer to clear the C. rodentium infection than D+ WT or D+ Cyp KO mice. Treating infected D- Cyp KO mice with IL-22 protected the mice from lethality. Treating the D- WT mice with 1,25D reconstituted the ILC3 cells in the colon and protected the mice from C. rodentium. IL-22 treatment of D- WT mice eliminated the need for vitamin D to clear the C. rodentium infection. Vitamin D is required for early IL-22 production from ILC3 cells and protection from enteric infection with C. rodentium.
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Metadata
- Authors
- Lin, Y.-D., Arora, J., Diehl, K., Bora, S. A., & Cantorna, M. T.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-01-22
- Volume
- 10
- Pages
- 1-1
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2910869058
- Cited by
- 601
- References
- 44
- FWCI
- 41.50
- Type
- journal article
- Language
- en
- Open access
- gold
- Funders
- National Institutes of Health
- U.S. Department of Agriculture
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- Lin, Y.-D., Arora, J., Diehl, K., Bora, S. A., & Cantorna, M. T. (2019). Vitamin D Is Required for ILC3 Derived IL-22 and Protection From Citrobacter rodentium Infection. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2019.00001
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