Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells
Open accessAbstract
Stem Cell Antigen-1 (Sca-1/Ly6A) was the first identified member of the Lymphocyte antigen-6 (Ly6) gene family. Sca-1 serves as a marker of cancer stem cells and tissue-resident stem cells in mice. The Sca-1 gene is located on mouse chromosome 15. While a direct homologue of Sca-1 in humans is missing, human chromosome 8 - the syntenic region to mouse chromosome 15 - harbors several genes containing the characteristic domain known as LU domain. The function of the LU domain in human LY6 gene family is not yet defined. The LY6 gene family proteins are present on human chromosome 6. 8, 11 and 19. The most interesting of these genes are located on chromosome 8q24.3, a frequently amplified locus in human cancer. Human LY6 genes represent novel biomarkers for poor cancer prognosis and are required for cancer progression in addition to playing an important role in immune escape. Although the mechanism associated with these phenotypes is not yet clear, it is timely to review the current literature in order to address the critical need for future advancements in this field. This review will summarize recent findings which describe the role of human LY6 genes - LY6D, LY6E, LY6H, LY6K, PSCA, LYPD2, SLURP1, GML, GPIHBP1 and LYNX1; and their orthologues in mice at chromosome 15.
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We identified and annotated 61 genes in the muskox MHC Class III region, including members of the TNF family, the Lymphocyte Antigen-6 family members, and the members of the complement cascade.
“We identified and annotated 61 genes in the muskox MHC Class III region, including members of the TNF family123,124, the Lymphocyte Antigen-6 family members125, and the members of the complement cascade.126”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [125]
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References 69 · Cited by 143
- Authors
- Upadhyay, G.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- Corresponding author
- Upadhyay, Geeta
- ORCID
- Upadhyay, Geeta
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-04-24
- Volume
- 10
- Pages
- 819-819
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC6491625
- OpenAlex
- W2934533555
- Cited by
- 143
- References
- 69
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 29 · 2023: 24 · 2022: 27 · 2021: 17 · 2020: 12 · 2019: 1
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Uniformed Services University of the Health Sciences (R01CA227694)
- National Cancer Institute (R01CA227694)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- cancer stem cells, tissue-resident stem cells, chromosome 15, tumor markers, cancer prognosis, tumor progression, immune evasion, immune cells
- MeSH terms
- Ataxin-1, Animals, Disease Susceptibility, Multigene Family, Humans, Lymphocytes, Neoplasms, Organ Specificity, Gene Expression Regulation, Neoplastic, Mice
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