The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
The Role of Inflammation in Depression and Fatigue
Open accessAbstract
Depression and fatigue are conditions responsible for heavy global societal burden, especially in patients already suffering from chronic diseases. These symptoms have been identified by those affected as some of the most disabling symptoms which affect the quality of life and productivity of the individual. While many factors play a role in the development of depression and fatigue, both have been associated with increased inflammatory activation of the immune system affecting both the periphery and the central nervous system (CNS). This is further supported by the well-described association between diseases that involve immune activation and these symptoms in autoimmune disorders, such as multiple sclerosis and immune system activation in response to infections, like sepsis. Treatments for depression also support this immunopsychiatric link. Antidepressants have been shown to decrease inflammation, while higher levels of baseline inflammation predict lower treatment efficacy for most treatments. Those patients with higher initial immune activation may on the other hand be more responsive to treatments targeting immune pathways, which have been found to be effective in treating depression and fatigue in some cases. These results show strong support for the hypothesis that depression and fatigue are associated with an increased activation of the immune system which may serve as a valid target for treatment. Further studies should focus on the pathways involved in these symptoms and the development of treatments that target those pathways will help us to better understand these conditions and devise more targeted treatments.
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Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
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From inflammation to sickness and depression: when the immune system subjugates the brain
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“Given that a third of depressed patients are treatment resistant even after four successive treatment steps (137), the exploration of the immune system as a treatment target is a legitimate area of interest, especially in those with higher baseline inflammation.”
BackgroundA Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
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The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942 · cited 1×
“The use of non-steroidal anti-inflammatory drugs (NSAIDs) as an add-on to standard antidepressant therapy should however be done carefully due to the role innate immune response plays in normal neurological functions (23), and especially since the antidepressant effect of SSRIs can be attenuated by anti-inflammatory t…”
BackgroundThe Prevalence of Comorbid Depression in Adults With Diabetes
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The Epidemiology of Depression Across Cultures
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Godos, J., Currenti, W., Angelino, D., Mena, P., Castellano, S., Caraci, F., Galvano, F., Del Rio, D., Ferri, R., & Grosso, G. (2020) · Antioxidants · doi:10.3390/antiox9040346 · Cited by 258
Immune-mediated inflammatory diseases: common and different pathogenic and clinical features
Monteleone, G., Moscardelli, A., Colella, A., Marafini, I., & Salvatori, S. (2023) · Autoimmunity Reviews · doi:10.1016/j.autrev.2023.103410 · Cited by 105
Biomarkers of post-covid depression
Lorkiewicz, P., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184142 · Cited by 102
Adaptation of Lipid Profiling in Depression Disease and Treatment: A Critical Review
Pinto, B., Conde, T., Domingues, I., & Domingues, M. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042032 · Cited by 51
“The use of antidepressants can reduce the levels of these pro-inflammatory mediators, which in turn may contribute to resolution of inflammation, and further attenuation of MDD [66,78,79].”
BackgroundSerum Interferon-Gamma Level Is Associated with Drug-Naïve Major Depressive Disorder
Daria, S., Proma, M. A., Shahriar, M., Islam, S. M. A., Bhuiyan, M. A., & Islam, M. R. (2020) · SAGE Open Medicine · doi:10.1177/2050312120974169 · Cited by 46
Metadata
- Authors
- Lee, C.-H., & Giuliani, F.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-07-19
- Volume
- 10
- Pages
- 1696-1696
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2961101336
- Cited by
- 640
- References
- 141
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
