The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression
Open accessAbstract
The pentraxin family is a superfamily consist of proteins with the same domain called the pentraxin domain at C-terminal. This family is divided into the short pentraxins (C-reactive protein and amyloid P component serum) and the long pentraxins (neuronal pentraxin 1, neuronal pentraxin 2, neuronal pentraxin receptor, pentraxin 3 and pentraxin 4), and each of them shares the similar structure, a pentameric complexes arranged in discoid shape. Previously researches revealed the functions of different family members such as most of the family members involve in human innate immunity, amyloid P component serum connects to amyloidosis disease. It is well known that inflammation is bound closely with tumor progression and the pentraxin family might participate in tumor progression. Therefore, we summarized the basic characteristics of this family, their function and their relationship with tumor in this review. And we discovered that the ways how this family affects tumor progression are different and this difference is highly connected with their unique structure.
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The involvement of NPTXs in tumour development might be related to the role of AMPAR in tumours, together with the inflammatory function of NPTXs.
“Notably, the involvement of these proteins in tumour development might be related to the role of AMPAR in tumours (Radin and Patel 2017; Wang et al. 2020), together with the inflammatory function of NPTXs.”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Wang et al. 2020
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References 139 · Cited by 73
- Authors
- Wang, Z., Wang, X., Zou, H., Dai, Z., Feng, S., Zhang, M., Xiao, G., Liu, Z., & Cheng, Q.
- Affiliations
- Central South University (CN)
- Sichuan University (CN)
- Corresponding author
- Xiao, Gelei
- Liu, Zhixiong
- Cheng, Quan
- ORCID
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-08-18
- Volume
- 11
- Pages
- 1757-1757
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3071939578
- Cited by
- 73
- References
- 139
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 12 · 2023: 20 · 2022: 14 · 2021: 8
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (2018JJ3838, 81803582, 81703622, C2019186)
- Central South University
- China Postdoctoral Science Foundation (81703622, C2019186, 2018JJ3838, 2018M63302)
- Natural Science Foundation of Hunan Province (81703622, C2019186, 2019JJ50949, 2018JJ3838)
- Xiangya Hospital, Central South University (2018JJ3838)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- C-reactive protein, serum amyloid P component, NPTX2, pentraxin 3, tumor progression, innate immunity, inflammation, amyloidosis, protein structure
- MeSH terms
- Pentraxins, Serum Amyloid P-Component, Animals, C-Reactive Protein, Humans, Immunity, Innate, Neoplasms, Nerve Tissue Proteins, Protein Conformation, Structure-Activity Relationship, Signal Transduction, Disease Progression, Tumor Microenvironment
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