CoChat
Sign Up
Cited by 341Oral microbiology and periodontitis researchHead and Neck Cancer StudiesBacterial Cancer Therapy

The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.

The Oral Microbiome and Cancer

Open access
Irfan, Muhammad, Delgado, Renata Zoraida Rizental, Frias-Lopez, Jorge·2020·Frontiers in Immunology
DOI 10.3389/fimmu.2020.591088PMC PMC7645040
Open this paper in CoChat — free accountOpen PDF

Abstract

There is mounting evidence that members of the human microbiome are highly associated with a wide variety of cancer types. Among oral cancers, oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied, and it is the most common malignancy of the head and neck worldwide. However, there is a void regarding the role that the oral microbiome may play in OSCC. Previous studies have not consistently found a characteristic oral microbiome composition associated with OSCC. Although a direct causality has not been proven, individual members of the oral microbiome are capable of promoting various tumorigenic functions related to cancer development. Two prominent oral pathogens, Porphyromonas gingivalis, and Fusobacterium nucleatum can promote tumor progression in mice. P. gingivalis infection has been associated with oro-digestive cancer, increased oral cancer invasion, and proliferation of oral cancer stem cells. The microbiome can influence the evolution of the disease by directly interacting with the human body and significantly altering the response and toxicity to various forms of cancer therapy. Recent studies have shown an association of certain phylogenetic groups with the immunotherapy treatment outcomes of certain tumors. On the other side of the coin, recently it has been a resurgence in interest on the potential use of bacteria to cure cancer. These kinds of treatments were used in the late nineteenth and early twentieth centuries as the first line of defense against cancer in some hospitals but later displaced by other types of treatments such as radiotherapy. Currently, organisms such as Salmonella typhimurium and Clostridium spp. have been used for targeted strategies as potential vectors to treat cancer. In this review, we briefly summarize our current knowledge of the role of the oral microbiome, focusing on its bacterial fraction, in cancer in general and in OSCC more precisely, and a brief description of the potential use of bacteria to target tumors.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fimmu.2020.591088

Cites

230 of 230 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Items 201–230 of 230

Flagged first, then by citations

Research works printed but not linked: 2

  1. Virchow, 1863, Die krankhaften Geschwülste: dreissig Vorlesungen, gehalten während des Wintersemesters 1862-1863 an der Universität zu Berlin
  2. Zebertavage, 2019, A microbial-based cancer vaccine for induction of EGFRvIII-specific CD8+ T cells and anti-tumor immunity, PLoS One, 14, 10.1371/journal.pone.0209153 · DOI

Cited by

Sorted by citations

See all 341

Related

See all

Metadata

Authors
Irfan, M., Delgado, R. Z. R., & Frias-Lopez, J.
Affiliations
University of Florida (US)
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2020-10-23
Volume
11
Pages
591088-591088
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2020.591088
PMC
PMC7645040
OpenAlex
W3094268377
Cited by
341
References
230
Citations by year
2026: 51 · 2025: 77 · 2024: 80 · 2023: 56 · 2022: 59 · 2021: 18
FWCI
5.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of Dental and Craniofacial Research
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords
oral microbiota, oral squamous cell carcinoma, Porphyromonas gingivalis, Fusobacterium nucleatum, oral pathogens, tumor progression, cancer stem cells, cancer immunotherapy response, cancer therapy toxicity, bacterial cancer therapy, Salmonella typhimurium, Clostridium, head and neck cancer
MeSH terms
Squamous Cell Carcinoma of Head and Neck, Animals, Combined Modality Therapy, Disease Susceptibility, Humans, Mouth Mucosa, Mouth Neoplasms, Neoplasms, Organ Specificity, Treatment Outcome, Disease Management, Host-Pathogen Interactions, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review