Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis

Myasoedova, Veronika A.; Massaiu, Ilaria; Moschetta, Donato; Chiesa, Mattia; Songia, Paola; Valerio, Vincenza; Alfieri, Valentina; Capoulade, Romain; Trabattoni, Daniela; Andreini, Daniele; Mass, Elvira; Parisi, Valentina; Poggio, Paolo

doi:10.3389/fimmu.2022.747714

Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis

Background Aortic stenosis (AS) is the most common valve disorder characterized by fibro-calcific remodeling of leaflets. Recent evidence indicated that there is a sex-related difference in AS development and progression. Fibrotic remodeling is peculiar in women’s aortic valves, while men’s leafl…