The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers
Open accessAbstract
Programmed cell death protein-1 (PD-1) is a checkpoint receptor expressed on the surface of various immune cells. PD-L1, the natural receptor for PD-1, is mainly expressed in tumor cells. Studies have indicated that PD-1 and PD-L1 are closely associated with the progression of human cancers and are promising biomarkers for cancer therapy. Moreover, the interaction of PD-1 and PD-L1 is one of the important mechanism by which human tumors generate immune escape. This article provides a review on the role of PD-L1/PD-1, mechanisms of immune response and resistance, as well as immune-related adverse events in the treatment of anti-PD-1/PD-L1 immunotherapy in human cancers. Moreover, we summarized a large number of clinical trials to successfully reveal that PD-1/PD-L1 Immune-checkpoint inhibitors have manifested promising therapeutic effects, which have been evaluated from different perspectives, including overall survival, objective effective rate and medium progression-free survival. Finally, we pointed out the current problems faced by PD-1/PD-L1 Immune-checkpoint inhibitors and its future prospects. Although PD-1/PD-L1 immune checkpoint inhibitors have been widely used in the treatment of human cancers, tough challenges still remain. Combination therapy and predictive models based on integrated biomarker determination theory may be the future directions for the application of PD-1/PD-L1 Immune-checkpoint inhibitors in treating human cancers.
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Citations
Cites
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
Brahmer, J. R., Tykodi, S. S., Chow, L. Q. M., Hwu, W.-J., Topalian, S. L., Hwu, P., Drake, C. G., Camacho, L. H., Kauh, J., Odunsi, K., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200694 · Cited by 7,945
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Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
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“The mechanisms may be closely associated with exhaustion and loss of T cell function (41–43), impaired processing or presentation of neoantigens (44), complexity of the tumor microenvironment (45), mutations in associated genes (46), dysbiosis of the gut microbiome (47), lack of Memory T Cells (48) and upregulation of…”
BackgroundTGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400
Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck
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Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer
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BackgroundPembrolizumab plus chemotherapy for squamous non-small-cell lung cancer
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Cited by
Abaza, A., Sid Idris, F., Anis Shaikh, H., Vahora, I., Moparthi, K. P., Al Rushaidi, M. T., Muddam, M. R., Obajeun, O. A., Jaramillo, A. P., & Khan, S. (2023) · Cureus · doi:10.7759/cureus.44582 · Cited by 59
The role of immune checkpoints in antitumor response: a potential antitumor immunotherapy
Mejía-Guarnizo, L. V., Monroy-Camacho, P. S., Turizo-Smith, A. D., & Rodríguez-García, J. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1298571 · Cited by 48
Wang, L.-M., Yang, C., Sun, X., Tian, Y., Zhang, J., Wang, X., Zhou, L., Wang, Z., Lin, Y., Wu, T., et al. (2025) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-24-0999 · Cited by 2
Metadata
- Authors
- Tang, Q., Chen, Y., Li, X., Long, S., Shi, Y., Yu, Y., Wu, W., Han, L., & Wang, S.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2022-09-13
- Volume
- 13
- Pages
- 964442-964442
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W4295540029
- Cited by
- 561
- References
- 27
- FWCI
- 39.79
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tang, Q., Chen, Y., Li, X., Long, S., Shi, Y., Yu, Y., Wu, W., Han, L., & Wang, S. (2022). The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2022.964442
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
