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Cited by 43Angiogenesis and VEGF in CancerMesenchymal stem cell researchTissue Engineering and Regenerative Medicine

The Vasoreparative Potential of Endothelial Colony Forming Cells: A Journey Through Pre-clinical Studies

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O'Neill, Christina L., McLoughlin, Kiran J., Chambers, Sarah E. J., Guduric-Fuchs, Jasenka, Stitt, Alan W., Medina, Reinhold J.·2018·Frontiers in Medicine
DOI 10.3389/fmed.2018.00273PMC PMC6232760
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Abstract

For over a decade various cell populations have been investigated for their vasoreparative potential. Cells with the capacity to promote blood vessel regeneration are commonly known as endothelial progenitor cells (EPCs); although such a definition is currently considered too simple for the complexity of cell populations involved in the reparative angiogenic process. A subset of EPCs called endothelial colony forming cells (ECFCs) have emerged as a suitable candidate for cytotherapy, primarily due to their clonogenic progenitor characteristics, unequivocal endothelial phenotype, and inherent ability to promote vasculogenesis. ECFCs can be readily isolated from human peripheral and cord blood, expanded ex vivo and used to revascularise ischaemic tissues. These cells have demonstrated efficacy in several in vivo preclinical models such as the ischaemic heart, retina, brain, limb, lung and kidney. This review will summarise the current pre-clinical evidence for ECFC cytotherapy and discuss their potential for clinical application.

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Cited by

Sorted by citations

Authors
O'Neill, C. L., McLoughlin, K. J., Chambers, S. E. J., Guduric-Fuchs, J., Stitt, A. W., & Medina, R. J.
Affiliations
Queen's University Belfast (GB)
Corresponding author
Medina, Reinhold J.
ORCID
Venue
Frontiers in Medicine
Publisher
Frontiers Media SA
Published
2018-10-16
Volume
5
Pages
273-273
ISSN
2296-858X (ISSN-L)
DOI
10.3389/fmed.2018.00273
PMC
PMC6232760
OpenAlex
W2889826867
Cited by
43
References
2
Citations by year
2026: 1 · 2025: 7 · 2024: 6 · 2023: 1 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 6 · 2018: 1
FWCI
0.56
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (Queen's University Belfast) (acceptedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Juvenile Diabetes Research Foundation
  • Leverhulme Trust
  • National Eye Research Centre
  • Fight for Sight UK
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
endothelial colony-forming cells, endothelial progenitor cells, cell therapy, angiogenesis, vasculogenesis, retinal ischemia, cerebral ischemia, limb ischemia, umbilical cord blood, peripheral blood, preclinical models

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