Roles of Macrophages and Exosomes in Liver Diseases
Open accessAbstract
Exosomes are small discoid extracellular vesicles (EVs) originating from endosomes that are 30-150 nm in diameter and have a double lipid layer. They participate in the immune response, cell migration, cell differentiation, and tumor invasion and mediate intercellular communication, regulating the biological activity of receptor cells through the proteins, nucleic acids, and lipids that they carry. Exosomes also play vital roles in the diagnosis and treatment of liver diseases. Macrophages, which show unique phenotypes and functions in complex microenvironments, can be divided into M1 and M2 subtypes. M1 macrophages function in immune surveillance, and M2 macrophages downregulate the immune response. Recent studies have shown that macrophages are involved in non-alcoholic fatty liver disease, liver fibrosis, and hepatocellular carcinoma. Moreover, several studies have demonstrated that liver diseases are associated with exosomes derived from or transferred to macrophages. This review focuses on the participation of macrophages and exosomes in liver diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The biofilm coverage of exosomes allows them to avoid degradation by macrophages, hence prolonging their circulation time.
“Furthermore, the biofilm coverage of exosomes allows them to avoid degradation by macrophages, hence prolonging their circulation time [76].”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [76]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 108 · Cited by 61
- Authors
- Shen, M., Shen, Y., Fan, X., Men, R., Ye, T., & Yang, L.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Ye, Tinghong
- Yang, Li
- Venue
- Frontiers in Medicine
- Publisher
- Frontiers Media SA
- Published
- 2020-09-24
- Volume
- 7
- Pages
- 583691-583691
- ISSN
- 2296-858X (ISSN-L)
- PMC
- PMC7542243
- OpenAlex
- W3087892596
- Cited by
- 61
- References
- 108
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 11 · 2023: 18 · 2022: 11 · 2021: 9
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- West China Hospital, Sichuan University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- macrophages, exosomes, extracellular vesicles, liver disease, M1 macrophages, M2 macrophages, non-alcoholic fatty liver disease, liver fibrosis, hepatocellular carcinoma, intercellular communication, macrophage-derived exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
