Day-4 antipseudomonal and anti-MRSA de-escalation was not associated with higher mortality in critically ill patients with sepsis

Zhang, Yuhang; Liao, Guoying; Song, Jianli; Liao, Yinsheng; Zhang, Lulu

doi:10.3389/fmed.2026.1924203

Day-4 antipseudomonal and anti-MRSA de-escalation was not associated with higher mortality in critically ill patients with sepsis

Background Broad empiric antibiotics are often appropriate at the start of intensive care unit (ICU) sepsis care; however, continued antipseudomonal or anti-methicillin-resistant Staphylococcus aureus (MRSA) coverage may no longer be justified by the day-4 reassessment. We examined antibiotic de-…