It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
Open accessAbstract
"Amphotericin B acts through pore formation at the cell membrane after binding to ergosterol" is an accepted dogma about the action mechanism of this antifungal, and this sentence is widely found in the literature. But after 60 years of investigation, the action mechanism of Amphotericin B is not fully elucidated. Amphotericin B is a polyene substance that is one of the most effective drugs for the treatment of fungal and parasite infections. As stated above, the first mechanism of action described was pore formation after binding to the ergosterol present in the membrane. But it has also been demonstrated that AmB induces oxidative damage in the cells. Moreover, amphotericin B modulates the immune system, and this activity has been related to the protective effect of the molecule, but also to its toxicity in the host. This review tries to provide a general overview of the main aspects of this molecule, and highlight the multiple effects that this molecule has on both the fungal and host cells.
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References 136 · Cited by 311
- Authors
- Mesa-Arango, A. C., Scorzoni, L., & Zaragoza, O.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 3
- Pages
- 286-286
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC3441194
- OpenAlex
- W2061894085
- Cited by
- 311
- References
- 136
- Citations by year
- 2026: 13 · 2025: 35 · 2024: 25 · 2023: 32 · 2022: 28 · 2021: 45 · 2020: 35 · 2019: 24 · 2018: 13 · 2017: 14 · 2016: 17 · 2015: 12 · 2014: 10 · 2013: 8
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Greater South Information System
- Funders
- Universidad de Antioquia
- Fundación Carolina
- Agencia Española de Cooperación Internacional para el Desarrollo
- FP7 International Cooperation
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- amphotericin B, antifungal agents, immunomodulation, mechanism of action, polyene antibiotics, ergosterol binding, pore formation, oxidative stress, host toxicity, fungal infection, parasitic infection
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