The DOI matches its Crossref record; 286 of the 286 references it cites were found in a registry or an index.
NADPH-generating systems in bacteria and archaea
Open accessAbstract
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms. It provides the reducing power that drives numerous anabolic reactions, including those responsible for the biosynthesis of all major cell components and many products in biotechnology. The efficient synthesis of many of these products, however, is limited by the rate of NADPH regeneration. Hence, a thorough understanding of the reactions involved in the generation of NADPH is required to increase its turnover through rational strain improvement. Traditionally, the main engineering targets for increasing NADPH availability have included the dehydrogenase reactions of the oxidative pentose phosphate pathway and the isocitrate dehydrogenase step of the tricarboxylic acid (TCA) cycle. However, the importance of alternative NADPH-generating reactions has recently become evident. In the current review, the major canonical and non-canonical reactions involved in the production and regeneration of NADPH in prokaryotes are described, and their key enzymes are discussed. In addition, an overview of how different enzymes have been applied to increase NADPH availability and thereby enhance productivity is provided.
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Cites
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Braissant, O., Astasov-Frauenhoffer, M., Waltimo, T., & Bonkat, G. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.547458 · Cited by 201
The Enzymatic Conversion of Major Algal and Cyanobacterial Carbohydrates to Bioethanol
Al Abdallah, Q., Nixon, B. T., & Fortwendel, J. R. (2016) · Frontiers in Energy Research · doi:10.3389/fenrg.2016.00036 · Cited by 102
Fenton, N. M., Qian, L., Paine, E. G., Sharpe, L. J., & Brown, A. J. (2024) · BioEssays · doi:10.1002/bies.202400073 · Cited by 7
Xie, F., Kiefer, A. F., Hirsch, A. K. H., Kalinina, O. V., Fu, C., & Müller, R. (2023) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2023.101394 · Cited by 5
Metadata
- Authors
- Spaans, S. K., Weusthuis, R. A., van der Oost, J., & Kengen, S. W. M.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2015-07-29
- Volume
- 6
- Pages
- 742-742
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W2166317358
- Cited by
- 373
- References
- 286
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
