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Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases
Open accessAbstract
The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways, where abnormal UPS function has been observed in cancer and neurological diseases. Many neurodegenerative diseases share a common pathological feature, namely intracellular ubiquitin-positive inclusions formed by aggregate-prone neurotoxic proteins. This suggests that dysfunction of the UPS in neurodegenerative diseases contributes to the accumulation of neurotoxic proteins and to instigate neurodegeneration. Here, we review recent findings describing various aspects of UPS dysregulation in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
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O'Mealey, G. B., Plafker, K. S., Berry, W. L., Janknecht, R., Chan, J. Y., & Plafker, S. M. (2017) · Journal of Cell Science · doi:10.1242/jcs.203216 · Cited by 99
Metadata
- Authors
- Zheng, Q., Huang, T., Zhang, L., Zhou, Y., Luo, H., Xu, H., & Wang, X.
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2016-12-15
- Volume
- 8
- Pages
- 303-303
- ISSN
- 1663-4365 (ISSN-L)
- OpenAlex
- W2560885607
- Cited by
- 311
- References
- 20
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zheng, Q., Huang, T., Zhang, L., Zhou, Y., Luo, H., Xu, H., & Wang, X. (2016). Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases. Frontiers in Aging Neuroscience. https://doi.org/10.3389/fnagi.2016.00303
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