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Cited by 46Blood transfusion and managementClinical Laboratory Practices and Quality ControlBlood donation and transfusion practices

The “Aging Factor” Eotaxin-1 (CCL11) Is Detectable in Transfusion Blood Products and Increases with the Donor’s Age

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Hoefer, Julia, Luger, Markus, Dal-Pont, Christian, Culig, Zoran, Schennach, Harald, Jochberger, Stefan·2017·Frontiers in Aging Neuroscience
DOI 10.3389/fnagi.2017.00402PMC PMC5717008
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Abstract

Background: High blood levels of the chemokine eotaxin-1 (CCL11) have recently been associated with ageing and dementia, as well as impaired memory and learning in humans. Importantly, eotaxin-1 was shown to pass the blood-brain-barrier and has been identified as crucial mediator of decreased neurogenesis and cognitive impairment in young mice after being surgically connected to the vessel system of old animals in a parabiosis model. It thus has to be assumed that sudden changes in eotaxin-1 levels between blood donors and recipients might influence cognitive functions also in humans. However, it is unknown if eotaxin-1 is stable during processing and storage of transfusion blood components. This study assesses eotaxin-1 concentrations in fresh-frozen plasma (FFP), erythrocyte concentrate (EC), and platelet concentrate (PC) in dependence of storage time as well as the donor`s age and gender. Methods: Eotaxin-1 was measured in FFP (n=168), EC (n=160) and PC (n=8) ready-to-use for transfusion employing a Q-Plex immunoassay for eotaxin-1. Absolute quantification of eotaxin-1 was performed with Q-view software. Results: Eotaxin-1 was consistently detected at a physiological level in FFP and EC but not PC. Eotaxin-1 levels were comparable in male and female donors but increased significantly with rising age of donors in both, FFP and EC. Furthermore, eotaxin-1 was not influenced by storage time of either blood component. Finally, eotaxin-1 is subject to only minor fluctuations within one donor over a longer period of time. Conclusion: Eotaxin-1 is detectable and stable in FFP and EC and increases with donor`s age. Considering the presumed involvement in ageing and cognitive malfunction, differences in donor- and recipient eotaxin-1 levels might affect mental factors after blood transfusion.

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Authors
Hoefer, J., Luger, M., Dal-Pont, C., Culig, Z., Schennach, H., & Jochberger, S.
Affiliations
  • Innsbruck Medical University (AT)
  • Universität Innsbruck (AT)
Corresponding author
Hoefer, Julia
ORCID
Venue
Frontiers in Aging Neuroscience
Publisher
Frontiers Media SA
Published
2017-12-01
Volume
9
Pages
402-402
ISSN
1663-4365 (ISSN-L)
DOI
10.3389/fnagi.2017.00402
PMC
PMC5717008
OpenAlex
W2771434252
Cited by
46
References
1
Citations by year
2026: 5 · 2025: 7 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 9 · 2019: 3 · 2018: 4
FWCI
2.96
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Aging Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Austrian Science Fund (T 738-BBL)
Topics
  • Health Sciences › Medicine › Biochemistry › Blood transfusion and management
  • Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
  • Social Sciences › Business, Management and Accounting › Management of Technology and Innovation › Blood donation and transfusion practices
Keywords
eotaxin, chemokines, blood transfusion, fresh frozen plasma, packed red blood cells, platelet concentrates, blood storage time, donor age, donor sex, cognitive impairment, dementia, aging, blood-brain barrier, parabiosis

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