Enteric nervous system: the bridge between the gut microbiota and neurological disorders
Open accessAbstract
The gastrointestinal (GI) tract plays an essential role in food digestion, absorption, and the mucosal immune system; it is also inhabited by a huge range of microbes. The GI tract is densely innervated by a network of 200-600 million neurons that comprise the enteric nervous system (ENS). This system cooperates with intestinal microbes, the intestinal immune system, and endocrine systems; it forms a complex network that is required to maintain a stable intestinal microenvironment. Understanding how gut microbes influence the ENS and central nervous system (CNS) has been a significant research subject over the past decade. Moreover, accumulating evidence from animal and clinical studies has revealed that gut microbiota play important roles in various neurological diseases. However, the causal relationship between microbial changes and neurological disorders currently remains unproven. This review aims to summarize the possible contributions of GI microbiota to the ENS and CNS. It also provides new insights into furthering our current understanding of neurological disorders.
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Microbes residing in the gut can activate stress circuits in the CNS through the vagus nerve and sensory neurons of the ENS.
“There is also evidence for signaling between the GM and CNS, since microbes residing in the gut can activate stress circuits in the CNS through the vagus nerve and sensory neurons of the ENS (21, 49–54).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [53]
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References 108 · Cited by 144
- Authors
- Geng, Z.-H., Zhu, Y., Li, Q.-L., Zhao, C., & Zhou, P.-H.
- Affiliations
- Fudan University (CN)
- Shanghai Medical College of Fudan University (CN)
- Corresponding author
- Li, Quan-Lin
- Zhao, Chao
- Zhou, Ping-Hong
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2022-04-19
- Volume
- 14
- Pages
- 810483-810483
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC9063565
- OpenAlex
- W4224305229
- Cited by
- 144
- References
- 108
- Citations by year
- 2026: 41 · 2025: 36 · 2024: 40 · 2023: 23 · 2022: 4
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Key Research and Development Program of China
- National Natural Science Foundation of China
- Shanghai Rising-Star Program
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- enteric nervous system, gut microbiota, neurological disorders, gut-brain axis, central nervous system, intestinal microenvironment, intestinal immunity
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