The choroid plexus—a multi-role player during infectious diseases of the CNS
Open accessAbstract
The choroid plexus (CP) is the source of cerebrospinal fluid (CSF) production and location of the blood-CSF barrier (BCSFB), which is constituted by the epithelial cells of the CP. Several infectious pathogens including viruses, bacteria, fungi and parasites cross the BCSFB to enter the central nervous system (CNS), ultimately leading to inflammatory infectious diseases like meningitis and meningoencephalitis. The CP responds to this challenge by the production of chemokines and cytokines as well as alterations of the barrier function of the BCSFB. During the course of CNS infectious disease host immune cells enter the CNS, eventually contributing to the cellular damage caused by the disease. Additional complications, which are in certain cases caused by choroid plexitis, can arise due to the response of the CP to the pathogens. In this review we will give an overview on the multiple functions of the CP during brain infections highlighting the CP as a multi-role player during infectious diseases of the CNS. In this context the importance of tools for investigation of these CP functions and a possible suitability of the CP as therapeutic target will be discussed.
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Pathogens can more easily enter the CNS through fenestrated blood vessels that lack tight junctions, such as those residing in the dura mater, choroid plexus, and CVOs.
“Pathogens can more easily enter the CNS through fenestrated blood vessels that lack tight junctions, such as those residing in the dura mater, choroid plexus, and CVOs (Fig. 1) (148).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [148]
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References 125 · Cited by 147
Research works printed but not linked: 2
- Ehrlich P. (1902). Über die Beziehung Chemischer Constitution, Vertheilung und Pharmakologischer Wirkung. Berlin: Hirschwald, 645– 679 (Republished in Gesammelte Werke Band I, by P. Ehrlich, 1956, Berlin, Heidelberg: Springer Verlag).
- Engelhardt B. Wolburg-Buchholz K. Wolburg H. (2001). Involvement of the choroid plexus in central nervous system inflammation. Microsc. Res. Tech. 52, 112– 129. 10.1002/1097-0029(20010101)52:1%3C112::AID-JEMT13%3E3.0.CO;2-5 11135454 · DOI
- Authors
- Schwerk, C., Tenenbaum, T., Kim, K. S., & Schroten, H.
- Affiliations
- Heidelberg University (DE)
- Johns Hopkins University (US)
- Corresponding author
- Kim, Kwang Sik
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-03-12
- Volume
- 9
- Pages
- 80-80
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4357259
- OpenAlex
- W2059672640
- Cited by
- 147
- References
- 125
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 18 · 2023: 18 · 2022: 16 · 2021: 11 · 2020: 16 · 2019: 13 · 2018: 10 · 2017: 14 · 2016: 14 · 2015: 3
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Allergy and Infectious Diseases (R21AI114925, R21AI113273)
- National Institute of Neurological Disorders and Stroke (R01NS091102)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- choroid plexus, blood-CSF barrier, cerebrospinal fluid production, central nervous system infection, meningitis, meningoencephalitis, chemokines, cytokines, barrier function, host immune cells, therapeutic target
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