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Cited by 130Lipid metabolism and biosynthesisSphingolipid Metabolism and SignalingCancer, Lipids, and Metabolism

Phosphatidic Acid: From Pleiotropic Functions to Neuronal Pathology

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Tanguy, Emeline, Wang, Qili, Moine, Hervé, Vitale, Nicolas·2019·Frontiers in Cellular Neuroscience
DOI 10.3389/fncel.2019.00002PMC PMC6351798
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Abstract

Among the cellular lipids, phosphatidic acid (PA) is a peculiar one as it is at the same time a key building block of phospholipid synthesis and a major lipid second messenger conveying signaling information. The latter is thought to largely occur through the ability of PA to recruit and/or activate specific proteins in restricted compartments and within those only at defined submembrane areas. Furthermore, with its cone-shaped geometry PA locally changes membrane topology and may thus be a key player in membrane trafficking events, especially in membrane fusion and fission steps, where lipid remodeling is believed to be crucial. These pleiotropic cellular functions of PA, including phospholipid synthesis and homeostasis together with important signaling activity, imply that perturbations of PA metabolism could lead to serious pathological conditions. In this mini-review article, after outlining the main cellular functions of PA, we highlight the different neurological diseases that could, at least in part, be attributed to an alteration in PA synthesis and/or catabolism.

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Authors
Tanguy, E., Wang, Q., Moine, H., & Vitale, N.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Vitale, Nicolas
ORCID
Venue
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Published
2019-01-23
Volume
13
Pages
2-2
ISSN
1662-5102 (ISSN-L)
DOI
10.3389/fncel.2019.00002
PMC
PMC6351798
OpenAlex
W2914242215
Cited by
130
References
1
Citations by year
2026: 9 · 2025: 14 · 2024: 18 · 2023: 20 · 2022: 22 · 2021: 20 · 2020: 18 · 2019: 9
FWCI
1.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Fondation pour la Recherche Médicale
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
phosphatidic acid, lipid second messengers, phospholipid synthesis, membrane trafficking, lipid remodeling, membrane topology, neuronal pathology, neurological disorders

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