Pleiotropic Roles of P2X7 in the Central Nervous System
Open accessAbstract
The purinergic receptor P2X7 is expressed in neural and immune cells known to be involved in neurological diseases. Its ligand, ATP, is a signaling molecule that can act as a neurotransmitter in physiological conditions or as a danger signal when released in high amount by damaged/dying cells or activated glial cells. Thus, ATP is a danger-associated molecular pattern. Binding of ATP by P2X7 leads to the activation of different biochemical pathways, depending on the physiological or pathological environment. The aim of this review is to discuss various functions of P2X7 in the immune and central nervous systems. We present evidence that P2X7 may have a detrimental or beneficial role in the nervous system, in the context of neurological pathologies: epilepsy, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, age-related macular degeneration and cerebral artery occlusion.
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Aberrant P2X7 receptor activation also induces VEGF release and signaling in the brain.
“Besides ACE2, aberrant P2X7 receptor activation also induces VEGF release and signaling in the brain [168].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [168]
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References 183 · Cited by 48
- Authors
- Kanellopoulos, J. M., & Delarasse, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Delarasse, Cécile
- ORCID
- Delarasse, Cécile
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2019-09-04
- Volume
- 13
- Pages
- 401-401
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC6738027
- OpenAlex
- W2969921857
- Cited by
- 48
- References
- 183
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 10 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 11
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-12-MALZ-0003, ANR-12)
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Université Paris-Saclay
- Sorbonne Université
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- P2X7 receptor, ATP, purinergic signaling, damage-associated molecular patterns, neuroinflammation, glial cells, epilepsy, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, age-related macular degeneration, cerebral artery occlusion, neurological disorders
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