High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons.
Open accessAbstract
This paper investigates the efficacy of high frequency switched-mode neural stimulation. Instead of using a constant stimulation amplitude, the stimulus is switched on and off repeatedly with a high frequency (up to 100 kHz) duty cycled signal. By means of tissue modeling that includes the dynamic properties of both the tissue material as well as the axon membrane, it is first shown that switched-mode stimulation depolarizes the cell membrane in a similar way as classical constant amplitude stimulation. These findings are subsequently verified using in vitro experiments in which the response of a Purkinje cell is measured due to a stimulation signal in the molecular layer of the cerebellum of a mouse. For this purpose a stimulator circuit is developed that is able to produce a monophasic high frequency switched-mode stimulation signal. The results confirm the modeling by showing that switched-mode stimulation is able to induce similar responses in the Purkinje cell as classical stimulation using a constant current source. This conclusion opens up possibilities for novel stimulation designs that can improve the performance of the stimulator circuitry. Care has to be taken to avoid losses in the system due to the higher operating frequency.
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The feasibility of high-frequency stimulation has been proved.
“Recently, the feasibility of high-frequency stimulation has been proved (van Dongen et al., 2015)”
From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as van Dongen et al., 2015
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References 28 · Cited by 15
- Authors
- van Dongen, M. N., Hoebeek, F. E., Koekkoek, S. K. E., De Zeeuw, C. I., & Serdijn, W. A.
- Affiliations
- Erasmus MC (NL)
- Delft University of Technology (NL)
- Venue
- Frontiers in Neuroengineering
- Publisher
- Frontiers Media SA
- Published
- 2015-03-06
- Volume
- 8
- Pages
- 2-2
- ISSN
- 1662-6443 (ISSN-L)
- PMC
- PMC4351622
- OpenAlex
- W2160147751
- Cited by
- 15
- References
- 28
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroengineering (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Research Repository (Delft University of Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- high-frequency stimulation, Purkinje cells, membrane depolarization, tissue modeling, cerebellar molecular layer, neurostimulation
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