Subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder: A double blind randomized controlled trial

Huang, Chun-Chao; Huang, Hui-Chun; Lin, Chen-Ju; Hsu, Chien-Chi; Lee, Chau-Shoun; Hsu, Yu-Hsin; Chen, Ting-Lin; Liao, Wei-Hsin; Wu, Yun-Hsiang; Yang, Fan-Pei Gloria; Liu, Shen-Ing

doi:10.3389/fneur.2022.979500

Subclinical alterations of resting state functional brain network for adjunctive bright light therapy in nonseasonal major depressive disorder: A double blind randomized controlled trial

Introduction The treatment effect of bright light therapy (BLT) on major depressive disorder (MDD) has been proven, but the underlying mechanism remains unclear. Neuroimaging biomarkers regarding disease alterations in MDD and treatment response are rarely focused on BLT. This study aimed to iden…